MetaCyc Pathway: FR-900098 and FR-33289 antibiotics biosynthesis in Cupriavidus basilensis FW507-4G11

Add experiment(s):


Phosphoenolpyruvate mutase:
phosphoenolpyruvate + H+→3-phosphonopyruvate (EC 5.4.2.9)
RR42_RS22445
3-phosphonopyruvate + acetyl-CoA + H2O→(R)-2-(phosphomethyl)malate + coenzyme A + H+ (EC 2.3.3.19)
No genes
(R)-2-(phosphomethyl)malate→3-phosphonomethylmalate
No genes
3-phosphonomethylmalate + an oxidized electron carrier + H+→2-oxo-4-phosphonobutanoate + CO2 + a reduced two electron carrier
No genes
2-oxo-4-phosphonobutanoate + an aminated amino group donor→2-amino-4-phosphonobutanoate + a deaminated amino group donor
No genes
2-amino-4-phosphonobutanoate + CTP + H+→CMP-5'-3-(aminopropyl)phosphonate + CO2 + diphosphate
No genes
CMP-5'-3-(aminopropyl)phosphonate + NADPH + dioxygen→CMP-5'-N-hydroxy-3-(aminopropyl)phosphonate + NADP+ + H2O
No genes
CMP-5'-N-hydroxy-3-(aminopropyl)phosphonate + acetyl-CoA→CMP-5'-3-(N-acetyl-N-hydroxy)aminopropylphosphonate + coenzyme A
No genes
CMP-5'-3-(N-acetyl-N-hydroxy)aminopropylphosphonate + H2O→FR-900098 + CMP + H+
No genes
FR-900098 + 2-oxoglutarate + dioxygen→FR-33289 + CO2 + succinate
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information