Anthranilate--CoA ligase:
anthranilate + ATP + coenzyme A→anthraniloyl-CoA + AMP + diphosphate (EC 6.2.1.32) |
| RR42_RS13535 |
| anthraniloyl-CoA + 2 malonyl-CoA + 2 H+→2-methyl-4-hydroxyquinoline + 3 CO2 + 3 coenzyme A |
| No genes |
| 2-methyl-4-hydroxyquinoline + (2E,6E)-farnesyl diphosphate→aurachin D + diphosphate |
| No genes |
| aurachin D + NADPH + dioxygen + H+→aurachin C + NADP+ + H2O |
| No genes |
| aurachin C + NAD(P)H + dioxygen + H+→aurachin C epoxide + NAD(P)+ + H2O (EC 1.14.13.222) |
| No genes |
| aurachin C epoxide→4-hydroxy-2-methyl-4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]quinolin-3(4H)-one 1-oxide (spontaneous) (EC 1.14.13.222) |
| No genes |
| 4-hydroxy-2-methyl-4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]quinolin-3(4H)-one 1-oxide→4-hydroxy-2-methyl-3-oxo-4-farnesyl-3,4-dihydroquinoline-1-oxide (EC 1.14.13.222) |
| No genes |
| 4-hydroxy-2-methyl-3-oxo-4-farnesyl-3,4-dihydroquinoline-1-oxide + NAD(P)H + H+→3,4-dihydroxy-2-methyl-4-farnesyl-3H-quinolin-1-ium-1-olate + NAD(P)+ (EC 1.1.1.394) |
| No genes |
| 3,4-dihydroxy-2-methyl-4-farnesyl-3H-quinolin-1-ium-1-olate→aurachin B + H2O (spontaneous) (EC 1.1.1.394) |
| No genes |
| aurachin B + NAD(P)H + dioxygen + H+→aurachin B epoxide + NAD(P)+ + H2O |
| No genes |
| aurachin B epoxide→aurachin A |
| No genes |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information