MetaCyc Pathway: superpathway of GDP-mannose-derived O-antigen building blocks biosynthesis in Cupriavidus basilensis FW507-4G11

Add experiment(s):


Glucose-6-phosphate isomerase:
α-D-glucose 6-phosphate→β-D-fructofuranose 6-phosphate
(EC 5.3.1.9)
RR42_RS03380
RR42_RS09060
Mannose-6-phosphate isomerase (in reverse):
β-D-fructofuranose 6-phosphate→D-mannopyranose 6-phosphate
(EC 5.3.1.8)
RR42_RS13685
RR42_RS21015
RR42_RS28130
RR42_RS33245
RR42_RS33375
RR42_RS34480
Phosphomannomutase (in reverse):
D-mannopyranose 6-phosphate→α-D-mannose 1-phosphate
(EC 5.4.2.8)
RR42_RS15690
Mannose-1-phosphate guanylyltransferase:
α-D-mannose 1-phosphate + GTP + H+→GDP-α-D-mannose + diphosphate
(EC 2.7.7.13)
RR42_RS21015
RR42_RS33245
RR42_RS34480
GDP-mannose 4,6-dehydratase:
GDP-α-D-mannose→GDP-4-dehydro-α-D-rhamnose + H2O
(EC 4.2.1.47)
RR42_RS21010
RR42_RS33235
RR42_RS34465
GDP-L-fucose synthase:
GDP-4-dehydro-α-D-rhamnose→GDP-4-dehydro-6-deoxy-β-L-galactose
(EC 1.1.1.271)
RR42_RS21005
RR42_RS33240
RR42_RS34460
GDP-4-dehydro-D-rhamnose reductase (in reverse):
GDP-4-dehydro-α-D-rhamnose + NAD(P)H + H+→GDP-α-D-rhamnose + NAD(P)+
(EC 1.1.1.187; 1.1.1.281)
No genes
GDP-6-deoxy-D-talose 4-dehydrogenase (in reverse):
GDP-4-dehydro-α-D-rhamnose + NAD(P)H + H+→GDP-6-deoxy-α-D-talose + NAD(P)+
(EC 1.1.1.135; 1.1.1.187)
No genes
GDP-4-dehydro-α-D-rhamnose + L-glutamate→GDP-α-D-perosamine + 2-oxoglutarate (EC 2.6.1.102)
No genes
GDP-4-dehydro-α-D-rhamnose + L-glutamate→2-GDP-[(2S,3S,6R)-5-amino-6-methyl-3,6-dihydro-2H-pyran-3-ol] + 2-oxoglutarate + H+ + H2O (EC 4.2.1.168)
No genes
GDP-L-fucose synthase (in reverse):
GDP-4-dehydro-6-deoxy-β-L-galactose + NADPH + H+→GDP-β-L-fucose + NADP+
(EC 1.1.1.271)
RR42_RS21005
RR42_RS33240
RR42_RS34460
2-GDP-[(2S,3S,6R)-5-amino-6-methyl-3,6-dihydro-2H-pyran-3-ol] + H+→2-GDP-[(2S,3S,6R)-5-imino-6-methyloxan-3-ol] (spontaneous) (EC 4.2.1.168)
No genes
2-GDP-[(2S,3S,6R)-5-imino-6-methyloxan-3-ol] + H2O→GDP-4-dehydro-3,6-dideoxy-α-D-mannose + ammonium (spontaneous) (EC 4.2.1.168)
No genes
GDP-4-dehydro-3,6-dideoxy-α-D-mannose + NAD(P)H + H+→GDP-β-colitose + NAD(P)+ (EC 1.1.1.356)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information