MetaCyc Pathway: ergothioneine biosynthesis I (bacteria) in Cupriavidus basilensis FW507-4G11

Add experiment(s):


Glutamate--cysteine ligase:
L-cysteine + ATP + L-glutamate→γ-L-glutamyl-L-cysteine + ADP + H+ + phosphate (EC 6.3.2.2)
RR42_RS01775
RR42_RS20100
Dimethylhistidine N-methyltransferase:
L-histidine + 3 S-adenosyl-L-methionine→hercynine + 3 S-adenosyl-L-homocysteine + 3 H+ (EC 2.1.1.44)
RR42_RS14730
hercynine + γ-L-glutamyl-L-cysteine + dioxygen→γ-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O (EC 1.14.99.50)
No genes
γ-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide + H2O→S-(hercyn-2-yl)-L-cysteine S-oxide + L-glutamate (EC 3.5.1.118)
No genes
S-(hercyn-2-yl)-L-cysteine S-oxide + H2O→2-(hydroxysulfanyl)hercynine + ammonium + pyruvate (EC 4.4.1.36)
No genes
2-(hydroxysulfanyl)hercynine + a reduced two electron carrier→ergothioneine + an oxidized electron carrier + H2O (spontaneous) (EC 4.4.1.36)
No genes
ergothioneine→ergothioneine (thione form) (spontaneous)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information