MetaCyc Pathway: superpathway of guanosine nucleotides de novo biosynthesis I in Cupriavidus basilensis FW507-4G11

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IMP dehydrogenase:
IMP + NAD+ + H2O→XMP + NADH + H+ (EC 1.1.1.205)
RR42_RS00320
RR42_RS06470
RR42_RS11750
GMP synthase (glutamine-hydrolyzing):
XMP + ATP + L-glutamine + H2O→GMP + AMP + L-glutamate + diphosphate + 2 H+ (EC 6.3.5.2)
RR42_RS11740
Guanylate kinase:
GMP + ATP→GDP + ADP (EC 2.7.4.8)
RR42_RS04905
RR42_RS04910
RR42_RS28065
Nucleoside-diphosphate kinase:
GDP + ATP→GTP + ADP (EC 2.7.4.6)
RR42_RS03445
RR42_RS13160
Ribonucleoside-diphosphate reductase (in reverse):
GDP + a reduced thioredoxin→dGDP + an oxidized thioredoxin + H2O (EC 1.17.4.1)
RR42_RS13290
RR42_RS17855
RR42_RS17860
Nucleoside-diphosphate kinase:
dGDP + ATP→dGTP + ADP (EC 2.7.4.6)
RR42_RS03445
RR42_RS13160

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information