MetaCyc Pathway: ceramide and sphingolipid recycling and degradation (yeast) in Cupriavidus basilensis FW507-4G11

Add experiment(s):


(4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-[(1D-myo-inositol-1-O-yl)hydroxyphosphoryl]sphinganine + H2O→a very-long-chain (2'R)-2'-hydroxy-phytoceramide + 1D-myo-inositol 1-monophosphate + H+
No genes
(4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-{[6-O-(α-D-mannosyl)-1D-myo-inositol-1-O-yl]hydroxyphosphoryl}sphinganine + H2O→a very-long-chain (2'R)-2'-hydroxy-phytoceramide + phosphoinositol-α-mannoside + H+
No genes
(4R)-4-hydroxy-N-[(2R)-2-hydroxy-very-long-chain-acyl]-1-O-[hydroxy(6-O-{6-O-[(1D-myo-inositol-1-O-yl)phosphoryl]-α-D-mannosyl}-1D-myo-inositol-1-O-yl)hydroxyphosphoryl]sphinganine + H2O→a very-long-chain (2'R)-2'-hydroxy-phytoceramide + phosphoinositol-α-mannoside-phosphoinositol
No genes
Ceramidase:
a dihydroceramide + H2O→sphinganine + a carboxylate (EC 3.5.1.23)
No genes
Ceramidase:
a very-long-chain (2'R)-2'-hydroxy-phytoceramide + H2O→a phytosphingosine + a very-long-chain (2R)-2-hydroxy fatty acid (EC 3.5.1.23)
No genes
Sphinganine kinase:
sphinganine + ATP→sphinganine 1-phosphate + ADP + H+ (EC 2.7.1.91)
No genes
sphinganine 1-phosphate + H2O→sphinganine + phosphate
No genes
Sphinganine kinase:
phytosphingosine + ATP→phytosphingosine (C18) 1-phosphate + ADP + H+ (EC 2.7.1.91)
No genes
Sphinganine-1-phosphate aldolase:
sphinganine 1-phosphate→hexadecanal + O-phosphoethanolamine (EC 4.1.2.27)
No genes
Sphinganine-1-phosphate aldolase:
phytosphingosine (C18) 1-phosphate→(R)-2-hydroxyhexadecanal + O-phosphoethanolamine (EC 4.1.2.27)
No genes
Aldehyde dehydrogenase (NAD(+)):
hexadecanal + NAD+ + H2O→palmitate + NADH + 2 H+ (EC 1.2.1.3)
RR42_RS01275
RR42_RS04280
RR42_RS11360
RR42_RS13660
RR42_RS18500
RR42_RS21485
RR42_RS23750
RR42_RS24065
RR42_RS24390
RR42_RS24705
RR42_RS24840
RR42_RS25005
RR42_RS25010
RR42_RS26255
RR42_RS27350
RR42_RS27780
RR42_RS29955
RR42_RS32140
RR42_RS34255
phytosphingosine (C18) 1-phosphate + H2O→phytosphingosine + phosphate
No genes
Aldehyde dehydrogenase (NAD(+)):
(R)-2-hydroxyhexadecanal + NAD+ + H2O→(R)-2-hydroxyhexadecanoate + NADH + 2 H+ (EC 1.2.1.3)
RR42_RS01275
RR42_RS04280
RR42_RS11360
RR42_RS13660
RR42_RS18500
RR42_RS21485
RR42_RS23750
RR42_RS24065
RR42_RS24390
RR42_RS24705
RR42_RS24840
RR42_RS25005
RR42_RS25010
RR42_RS26255
RR42_RS27350
RR42_RS27780
RR42_RS29955
RR42_RS32140
RR42_RS34255
Long-chain-fatty-acid--CoA ligase:
palmitate + ATP + coenzyme A→palmitoyl-CoA + AMP + diphosphate (EC 6.2.1.3)
RR42_RS01625
RR42_RS16170
RR42_RS16600
RR42_RS18150
RR42_RS18540
RR42_RS25195
RR42_RS26915
RR42_RS28980
RR42_RS29035
RR42_RS29460
RR42_RS29475
RR42_RS36095
RR42_RS36385
RR42_RS36505
(R)-2-hydroxyhexadecanoate + dioxygen→pentadecanoate + CO2 + H2O (EC 1.14.18.12)
No genes
Long-chain-fatty-acid--CoA ligase:
pentadecanoate + ATP + coenzyme A→pentadecanoyl-CoA + AMP + diphosphate (EC 6.2.1.3)
RR42_RS01625
RR42_RS18150
RR42_RS18540
RR42_RS25195
RR42_RS26915
RR42_RS28980
RR42_RS29035
RR42_RS29460
RR42_RS29475
RR42_RS36095
RR42_RS36385
RR42_RS36505

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information