MetaCyc Pathway: methyl ketone biosynthesis (engineered) in Cupriavidus basilensis FW507-4G11

Add experiment(s):


a fatty acid + ATP + coenzyme A→an acyl-CoA + AMP + diphosphate
No genes
Acyl-CoA oxidase:
a 2,3,4-saturated fatty acyl CoA + dioxygen→a (2E)-2-enoyl-CoA + hydrogen peroxide
(EC 1.3.3.6)
No genes
Enoyl-CoA hydratase (in reverse):
a (2E)-2-enoyl-CoA + H2O→a 2,3,4-saturated (3S)-3-hydroxyacyl-CoA
(EC 4.2.1.17)
RR42_RS00730
RR42_RS02510
RR42_RS02525
RR42_RS03015
RR42_RS04550
RR42_RS05755
RR42_RS05760
RR42_RS07510
RR42_RS10250
RR42_RS10265
RR42_RS10270
RR42_RS11095
RR42_RS12500
RR42_RS12795
RR42_RS13545
RR42_RS16175
RR42_RS16790
RR42_RS18250
RR42_RS18255
RR42_RS19805
RR42_RS19815
RR42_RS22630
RR42_RS22680
RR42_RS23295
RR42_RS23450
RR42_RS23710
RR42_RS24355
RR42_RS24895
RR42_RS25480
RR42_RS25525
RR42_RS25900
RR42_RS28050
RR42_RS28325
RR42_RS28330
RR42_RS28425
RR42_RS28545
RR42_RS28550
RR42_RS29425
RR42_RS29465
RR42_RS29940
RR42_RS29945
RR42_RS31580
RR42_RS31675
RR42_RS31935
RR42_RS31945
RR42_RS34175
RR42_RS34180
RR42_RS34905
RR42_RS35130
RR42_RS35270
RR42_RS36335
RR42_RS36495
3-hydroxyacyl-CoA dehydrogenase:
a 2,3,4-saturated (3S)-3-hydroxyacyl-CoA + NAD+→a 2,3,4-saturated 3-oxoacyl-CoA + NADH + H+
(EC 1.1.1.35)
RR42_RS02510
RR42_RS03005
RR42_RS03440
RR42_RS05760
RR42_RS10265
RR42_RS11095
RR42_RS22630
RR42_RS25375
RR42_RS28325
RR42_RS29465
RR42_RS31050
RR42_RS35270
a 2,3,4-saturated 3-oxoacyl-CoA + H2O→a 3-oxoacid + coenzyme A + H+
No genes
a 3-oxoacid + H+→a methyl ketone + CO2 (spontaneous)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information