MetaCyc Pathway: glycerol degradation to butanol in Cupriavidus basilensis FW507-4G11

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Glycerol dehydrogenase:
glycerol + NAD+→dihydroxyacetone + NADH + H+ (EC 1.1.1.6)
No genes
Glycerone kinase:
dihydroxyacetone + ATP→glycerone phosphate + ADP + H+ (EC 2.7.1.29)
No genes
Triose-phosphate isomerase (in reverse):
glycerone phosphate→D-glyceraldehyde 3-phosphate (EC 5.3.1.1)
RR42_RS05495
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating):
D-glyceraldehyde 3-phosphate + NAD+ + phosphate→3-phospho-D-glyceroyl phosphate + NADH + H+ (EC 1.2.1.12)
RR42_RS17570
Phosphoglycerate kinase (in reverse):
3-phospho-D-glyceroyl phosphate + ADP→3-phospho-D-glycerate + ATP (EC 2.7.2.3)
RR42_RS03200
3-phospho-D-glycerate→2-phospho-D-glycerate (EC 5.4.2.12)
RR42_RS01825
Phosphopyruvate hydratase:
2-phospho-D-glycerate→phosphoenolpyruvate + H2O (EC 4.2.1.11)
RR42_RS06175
RR42_RS33730
Pyruvate kinase (in reverse):
phosphoenolpyruvate + ADP + H+→pyruvate + ATP (EC 2.7.1.40)
RR42_RS03210
RR42_RS19870
RR42_RS33735
Pyruvate synthase:
pyruvate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster→acetyl-CoA + CO2 + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.2.7.1)
No genes
Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)
RR42_RS00885
RR42_RS02515
RR42_RS03010
RR42_RS07610
RR42_RS07645
RR42_RS10260
RR42_RS10540
RR42_RS11085
RR42_RS16595
RR42_RS22625
RR42_RS24300
RR42_RS24970
RR42_RS25210
RR42_RS25380
RR42_RS25455
RR42_RS26090
RR42_RS27160
RR42_RS27235
RR42_RS28055
RR42_RS28390
RR42_RS31890
RR42_RS31920
RR42_RS35915
RR42_RS36320
RR42_RS37020
3-hydroxyacyl-CoA dehydrogenase (in reverse):
acetoacetyl-CoA + NADH + H+→(S)-3-hydroxybutanoyl-CoA + NAD+ (EC 1.1.1.35)
RR42_RS01610
RR42_RS02510
RR42_RS03005
RR42_RS03440
RR42_RS05760
RR42_RS10265
RR42_RS11095
RR42_RS22630
RR42_RS24305
RR42_RS25375
RR42_RS28325
RR42_RS29465
RR42_RS31050
RR42_RS35270
(S)-3-hydroxybutanoyl-CoA→crotonyl-CoA + H2O (EC 4.2.1.150)
RR42_RS00730
RR42_RS02510
RR42_RS02525
RR42_RS03015
RR42_RS04550
RR42_RS05755
RR42_RS10250
RR42_RS10265
RR42_RS10270
RR42_RS11095
RR42_RS12500
RR42_RS12795
RR42_RS13545
RR42_RS16175
RR42_RS16790
RR42_RS18250
RR42_RS19805
RR42_RS22630
RR42_RS22680
RR42_RS23295
RR42_RS23450
RR42_RS23710
RR42_RS24355
RR42_RS24895
RR42_RS25480
RR42_RS25525
RR42_RS25900
RR42_RS28050
RR42_RS28325
RR42_RS28330
RR42_RS29425
RR42_RS29465
RR42_RS29940
RR42_RS29945
RR42_RS31580
RR42_RS31935
RR42_RS31945
RR42_RS34175
RR42_RS34180
RR42_RS34905
RR42_RS35270
RR42_RS36495
crotonyl-CoA[cytosol] + 2 NADH[cytosol] + 2 an oxidized ferredoxin [iron-sulfur] cluster[cytosol]→butanoyl-CoA[cytosol] + 2 NAD+[cytosol] + 2 a reduced ferredoxin [iron-sulfur] cluster[cytosol] (EC 1.3.1.109)
No genes
Butanal dehydrogenase (in reverse):
butanoyl-CoA + NAD(P)H + H+→1-butanal + coenzyme A + NAD(P)+ (EC 1.2.1.57)
No genes
Alcohol dehydrogenase (NADP(+)) (in reverse):
1-butanal + NADPH + H+→butan-1-ol + NADP+ (EC 1.1.1.2)
No genes
1-butanal + NADH + H+→butan-1-ol + NAD+
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information