MetaCyc Pathway: 5-hydroxymethylfurfural degradation in Cupriavidus basilensis FW507-4G11

Add experiment(s):


5-hydroxymethylfurfural + dioxygen→furan-2,5-dicarbaldehyde + hydrogen peroxide (EC 1.1.3.47)
No genes
furan-2,5-dicarbaldehyde + H2O→5-(dihydroxymethyl)furan-2-carbaldehyde (spontaneous) (EC 1.1.3.47)
No genes
5-(dihydroxymethyl)furan-2-carbaldehyde + dioxygen→5-formylfuran-2-carboxylate + hydrogen peroxide + H+ (EC 1.1.3.47)
No genes
5-formylfuran-2-carboxylate + H2O→5-(dihydroxymethyl)furan-2-carboxylate (spontaneous) (EC 1.1.3.47)
No genes
5-(dihydroxymethyl)furan-2-carboxylate + dioxygen→furan-2,5-dicarboxylate + hydrogen peroxide + H+ (EC 1.1.3.47)
No genes
furan-2,5-dicarboxylate + H+→2-furoate + CO2
RR42_RS30200
2-furoate--CoA ligase:
2-furoate + ATP + coenzyme A→2-furoyl-CoA + AMP + diphosphate (EC 6.2.1.31)
No genes
2-furoyl-CoA dehydrogenase:
2-furoyl-CoA + an oxidized electron carrier + H2O→S-(5-hydroxy-2-furoyl)-CoA + a reduced two electron carrier (EC 1.3.99.8)
No genes
S-(5-hydroxy-2-furoyl)-CoA + H2O→2-oxoglutaryl-CoA + H+
No genes
2-oxoglutaryl-CoA + H2O→2-oxoglutarate + coenzyme A + H+
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information