MetaCyc Pathway: threo-tetrahydrobiopterin biosynthesis in Cupriavidus basilensis FW507-4G11

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GTP cyclohydrolase I:
GTP + H2O→7,8-dihydroneopterin 3'-triphosphate + formate + H+ (EC 3.5.4.16)
RR42_RS15000
RR42_RS34345
6-pyruvoyltetrahydropterin synthase:
7,8-dihydroneopterin 3'-triphosphate→(6R)-6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate (EC 4.2.3.12)
RR42_RS11385
Sepiapterin reductase (in reverse):
(6R)-6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH + H+→(6R)-6-lactoyl-5,6,7,8-tetrahydropterin + NADP+ (EC 1.1.1.153; 1.1.1.220; 1.1.1.325)
No genes
(6R)-6-lactoyl-5,6,7,8-tetrahydropterin + NADPH + H+→(6R)-L-threo-5,6,7,8-tetrahydrobiopterin + NADP+ (EC 1.1.1.325)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information