MetaCyc Pathway: neopentalenoketolactone and pentalenate biosynthesis in Cupriavidus basilensis FW507-4G11

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Pentalenene synthase:
(2E,6E)-farnesyl diphosphate→pentalenene + diphosphate (EC 4.2.3.7)
No genes
pentalenene + dioxygen + 2 H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→pentalen-13-ol + 2 an oxidized ferredoxin [iron-sulfur] cluster + H2O (EC 1.14.15.32)
No genes
pentalen-13-ol + dioxygen + 2 H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→pentalen-13-al + 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 H2O (EC 1.14.15.32)
No genes
pentalen-13-al + dioxygen + H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→1-deoxypentalenate + 2 an oxidized ferredoxin [iron-sulfur] cluster + H2O
No genes
1-deoxypentalenate + 2-oxoglutarate + dioxygen→1-deoxy-11β-hydroxypentalenate + CO2 + succinate (EC 1.14.11.35)
No genes
1-deoxypentalenate + dioxygen + 2 H+ + 2 a reduced ferredoxin [iron-sulfur] cluster→pentalenate + 2 an oxidized ferredoxin [iron-sulfur] cluster + H2O (EC 1.14.15.11)
RR42_RS29925
1-deoxy-11β-hydroxypentalenate + NAD+→1-deoxy-11-oxopentalenate + NADH + H+ (EC 1.1.1.340)
No genes
1-deoxy-11-oxopentalenate + NADPH + dioxygen + H+→neopentalenolactone D + NADP+ + H2O (EC 1.14.13.171)
No genes
neopentalenolactone D + 2-oxoglutarate + dioxygen→neopentalenolactone E + CO2 + succinate + H2O
No genes
neopentalenolactone E + 2-oxoglutarate + dioxygen→neopentalenolactone F + CO2 + succinate
No genes
neopentalenolactone F→neopentalenoketolactone (spontaneous)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information