MetaCyc Pathway: candicidin biosynthesis in Cupriavidus basilensis FW507-4G11

Add experiment(s):


4-aminobenzoate + ATP + coenzyme A→4-aminobenzoyl-CoA + ADP + phosphate
No genes
acetyl-CoA + a [carboxyl-carrier protein dimer]-N6-carboxybiotinyl-L-lysine→malonyl-CoA + a [biotin carboxyl-carrier-protein dimer]-N6-biotinyl-L-lysine (EC 2.1.3.15)
RR42_RS06360
RR42_RS14345
4-aminobenzoyl-CoA + 15 malonyl-CoA + 4 (S)-methylmalonyl-CoA + 28 NADPH + 47 H+→candicinolide + 15 CO2 + 20 coenzyme A + 28 NADP+ + 16 H2O
No genes
candicinolide + 3 dioxygen + 5 H+ + 6 a reduced ferredoxin [iron-sulfur] cluster→18-carboxy candicinolide + 6 an oxidized ferredoxin [iron-sulfur] cluster + 4 H2O
No genes
18-carboxy candicinolide + a reduced two electron carrier + dioxygen→demycosaminyl-candicidin III + an oxidized electron carrier + H2O
No genes
demycosaminyl-candicidin III + GDP-mycosamine→candicidin III + GDP + H+
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information