GTP cyclohydrolase I:
GTP + H2O→7,8-dihydroneopterin 3'-triphosphate + formate + H+ (EC 3.5.4.16) |
| RR42_RS15000 |
| RR42_RS34345 |
Aminodeoxychorismate synthase:
chorismate + L-glutamine→4-amino-4-deoxychorismate + L-glutamate (EC 2.6.1.85) |
| RR42_RS17265 |
| RR42_RS18300 |
Aminodeoxychorismate lyase:
4-amino-4-deoxychorismate→4-aminobenzoate + H+ + pyruvate (EC 4.1.3.38) |
| RR42_RS16495 |
| RR42_RS17265 |
| 7,8-dihydroneopterin 3'-triphosphate + H2O→7,8-dihydroneopterin 3'-phosphate + diphosphate + H+ (EC 3.6.1.67) |
| RR42_RS02470 |
| 7,8-dihydroneopterin 3'-phosphate + H2O→D-erythro-7,8-dihydroneopterin + phosphate |
| No genes |
Dihydroneopterin aldolase:
D-erythro-7,8-dihydroneopterin→6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde (EC 4.1.2.25) |
| RR42_RS01440 |
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase:
6-(hydroxymethyl)-7,8-dihydropterin + ATP→(7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H+ (EC 2.7.6.3) |
| RR42_RS17240 |
Dihydropteroate synthase:
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate→7,8-dihydropteroate + diphosphate (EC 2.5.1.15) |
| RR42_RS13480 |
Dihydrofolate synthase:
7,8-dihydropteroate + ATP + L-glutamate→7,8-dihydrofolate monoglutamate + ADP + H+ + phosphate (EC 6.3.2.12) |
| RR42_RS14340 |
Dihydrofolate reductase (in reverse):
a 7,8-dihydrofolate + NADPH + H+→a tetrahydrofolate + NADP+ (EC 1.5.1.3) |
| RR42_RS01435 |
| RR42_RS14745 |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information