MetaCyc Pathway: superpathway of <i>Clostridium acetobutylicum</i> acidogenic and solventogenic fermentation in Cupriavidus basilensis FW507-4G11

MetaCyc Pathway: superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation in Cupriavidus basilensis FW507-4G11

Pyruvate synthase:
pyruvate + coenzyme A + 2 an oxidized ferredoxin [iron-sulfur] cluster→acetyl-CoA + CO₂ + H⁺ + 2 a reduced ferredoxin [iron-sulfur] cluster (EC 1.2.7.1)

No genes

Acetaldehyde dehydrogenase (acetylating) (in reverse):
acetyl-CoA + NADH + H⁺→acetaldehyde + coenzyme A + NAD⁺ (EC 1.2.1.10)

Acetyl-CoA C-acyltransferase:
2 acetyl-CoA→acetoacetyl-CoA + coenzyme A (EC 2.3.1.16; 2.3.1.9)

Phosphate acetyltransferase:
acetyl-CoA + phosphate→acetyl phosphate + coenzyme A (EC 2.3.1.8)

Acetate kinase (in reverse):
acetyl phosphate + ADP→acetate + ATP (EC 2.7.2.1; 2.7.2.15)

Alcohol dehydrogenase (in reverse):
acetaldehyde + NADH + H⁺→ethanol + NAD⁺ (EC 1.1.1.1)

3-hydroxyacyl-CoA dehydrogenase (in reverse):
acetoacetyl-CoA + NADH + H⁺→(S)-3-hydroxybutanoyl-CoA + NAD⁺ (EC 1.1.1.35)

Butyrate--acetoacetate CoA-transferase (in reverse):
acetate + acetoacetyl-CoA→acetyl-CoA + acetoacetate (EC 2.8.3.9)

(S)-3-hydroxybutanoyl-CoA→crotonyl-CoA + H₂O (EC 4.2.1.150)

crotonyl-CoA_[cytosol] + 2 NADH_[cytosol] + 2 an oxidized ferredoxin [iron-sulfur] cluster_[cytosol]→butanoyl-CoA_[cytosol] + 2 NAD⁺_[cytosol] + 2 a reduced ferredoxin [iron-sulfur] cluster_[cytosol] (EC 1.3.1.109)

No genes

Butanal dehydrogenase (in reverse):
butanoyl-CoA + NAD(P)H + H⁺→1-butanal + coenzyme A + NAD(P)⁺ (EC 1.2.1.57)

No genes

Phosphate butyryltransferase:
butanoyl-CoA + phosphate→butanoyl phosphate + coenzyme A (EC 2.3.1.19)

Branched-chain-fatty-acid kinase (in reverse):
butanoyl phosphate + ADP→butanoate + ATP (EC 2.7.2.14; 2.7.2.7)

No genes

Alcohol dehydrogenase (NADP(+)) (in reverse):
1-butanal + NADPH + H⁺→butan-1-ol + NADP⁺ (EC 1.1.1.2)

No genes

1-butanal + NADH + H⁺→butan-1-ol + NAD⁺

No genes

Butyrate--acetoacetate CoA-transferase (in reverse):
acetoacetyl-CoA + butanoate→acetoacetate + butanoyl-CoA (EC 2.8.3.9)

No genes

Acetoacetate decarboxylase:
acetoacetate + H⁺→acetone + CO₂ (EC 4.1.1.4)

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information