Tryptophan 2,3-dioxygenase:
L-tryptophan + dioxygen→N-formyl-L-kynurenine (EC 1.13.11.11; 1.13.11.52) |
| RR42_RS15390 |
Arylformamidase:
N-formyl-L-kynurenine + H2O→L-kynurenine + formate + H+ (EC 3.5.1.9) |
| RR42_RS15380 |
| RR42_RS33590 |
Kynureninase:
L-kynurenine + H2O→anthranilate + L-alanine + H+ (EC 3.7.1.3) |
| RR42_RS15385 |
| anthranilate + FADH2 + dioxygen→3-hydroxyanthranilate + FAD + H+ + H2O (EC 1.14.14.8) |
| No genes |
3-hydroxyanthranilate 3,4-dioxygenase:
3-hydroxyanthranilate + dioxygen→2-amino-3-carboxymuconate-6-semialdehyde (EC 1.13.11.6) |
| RR42_RS05080 |
Aminocarboxymuconate-semialdehyde decarboxylase:
2-amino-3-carboxymuconate-6-semialdehyde + H+→(2Z,4E)-2-amino-6-oxohexa-2,4-dienoate + CO2 (EC 4.1.1.45) |
| RR42_RS05075 |
| RR42_RS26470 |
Aminomuconate-semialdehyde dehydrogenase:
(2Z,4E)-2-amino-6-oxohexa-2,4-dienoate + NAD+ + H2O→(2Z,4E)-2-aminomuconate + NADH + 2 H+ (EC 1.2.1.32) |
| RR42_RS05110 |
| RR42_RS32650 |
2-aminomuconate deaminase:
(2Z,4E)-2-aminomuconate + H2O→(3E)-2-oxohex-3-enedioate + ammonium (EC 3.5.99.5) |
| RR42_RS05085 |
4-oxalocrotonate decarboxylase:
(3E)-2-oxohex-3-enedioate + H+→(2Z)-2-hydroxypenta-2,4-dienoate + CO2 (EC 4.1.1.77) |
| RR42_RS05105 |
| RR42_RS31850 |
| RR42_RS32640 |
| RR42_RS32645 |
2-oxopent-4-enoate hydratase (in reverse):
(2Z)-2-hydroxypenta-2,4-dienoate + H2O→(S)-4-hydroxy-2-oxopentanoate (EC 4.2.1.80) |
| RR42_RS05105 |
| RR42_RS27885 |
| RR42_RS32645 |
| RR42_RS34355 |
4-hydroxy-2-oxovalerate aldolase:
(S)-4-hydroxy-2-oxopentanoate→acetaldehyde + pyruvate (EC 4.1.3.39) |
| RR42_RS05095 |
| RR42_RS27900 |
| RR42_RS31860 |
| RR42_RS32625 |
Acetaldehyde dehydrogenase (acetylating):
acetaldehyde + coenzyme A + NAD+→acetyl-CoA + NADH + H+ (EC 1.2.1.10) |
| RR42_RS05100 |
| RR42_RS27895 |
| RR42_RS31855 |
| RR42_RS32630 |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information