MetaCyc Pathway: curcuminoid biosynthesis in Cupriavidus basilensis FW507-4G11

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4-coumarate--CoA ligase:
4-coumarate + ATP + coenzyme A→(E)-4-coumaroyl-CoA + AMP + diphosphate (EC 6.2.1.12)
RR42_RS36410
Caffeoyl-CoA O-methyltransferase:
(E)-caffeoyl-CoA + S-adenosyl-L-methionine→feruloyl-CoA + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.104)
No genes
(E)-4-coumaroyl-CoA + malonyl-CoA + H+→4-coumaroylacetyl-CoA + CO2 + coenzyme A (EC 2.3.1.218)
No genes
feruloyl-CoA + malonyl-CoA + H+→feruloylacetyl-CoA + CO2 + coenzyme A (EC 2.3.1.218)
No genes
4-coumaroylacetyl-CoA + H2O→4-coumaroyl-diketide + coenzyme A + H+ (EC 2.3.1.217; 2.3.1.219)
No genes
feruloylacetyl-CoA + H2O→feruloyl diketide + coenzyme A + H+ (EC 2.3.1.217; 2.3.1.219)
No genes
feruloyl diketide + feruloyl-CoA + H+→curcumin + CO2 + coenzyme A (EC 2.3.1.217)
No genes
feruloyl diketide + (E)-4-coumaroyl-CoA + H+→demethoxycurcumin + CO2 + coenzyme A (EC 2.3.1.219)
No genes
4-coumaroyl-diketide + (E)-4-coumaroyl-CoA + H+→bisdemethoxycurcumin + CO2 + coenzyme A (EC 2.3.1.219)
No genes
4-coumaroyl-diketide + feruloyl-CoA + H+→demethoxycurcumin + CO2 + coenzyme A (EC 2.3.1.217)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information