MetaCyc Pathway: pyochelin biosynthesis in Cupriavidus basilensis FW507-4G11

Add experiment(s):


salicylate + ATP + H+→(salicyl)adenylate + diphosphate (EC 6.2.1.61; 6.2.1.65)
No genes
Cysteine--tRNA ligase:
L-cysteine + ATP + H+→(L-cysteinyl)adenylate + diphosphate (EC 6.1.1.16; 6.2.1.69)
RR42_RS06350
(L-cysteinyl)adenylate + a [PchF non-ribosomal peptide synthase protein]→an L-cysteinyl-[PchF non-ribosomal peptide synthase] + AMP + H+ (EC 6.2.1.69)
No genes
(L-cysteinyl)adenylate + a [PchE non-ribosomal peptide synthase]→an L-cysteinyl-[PchE non-ribosomal peptide synthase] + AMP + H+ (EC 6.2.1.69)
No genes
(salicyl)adenylate + a [PchE non-ribosomal peptide synthase]→a salicyl-[PchE non-ribosomal peptide synthase] + AMP + H+ (EC 6.2.1.61)
No genes
an L-cysteinyl-[PchE non-ribosomal peptide synthase] + a salicyl-[PchE non-ribosomal peptide synthase]→salicyl-L-cysteinyl-[PchE non-ribosomal peptide synthas] + H+ + a [PchE non-ribosomal peptide synthase]
No genes
salicyl-L-cysteinyl-[PchE non-ribosomal peptide synthas]→hydroxyphenyl-thiazolinyl-[PchE non-ribosomal peptide synthase] + H2O
No genes
an L-cysteinyl-[PchF non-ribosomal peptide synthase] + hydroxyphenyl-thiazolinyl-[PchE non-ribosomal peptide synthase]→hydroxyphenyl-4,2-bis-thiazolinyl-[PchF non-ribosomal peptide synthase] + H+ + a [PchE non-ribosomal peptide synthase] + H2O
No genes
hydroxyphenyl-4,2-bis-thiazolinyl-[PchF non-ribosomal peptide synthase] + NADPH + H+→N-desmethyl-pyochelin-[PchF non-ribosomal peptide synthase] + NADP+
No genes
N-desmethyl-pyochelin-[PchF non-ribosomal peptide synthase] + S-adenosyl-L-methionine→pyochelinyl-[PchF non-ribosomal peptide synthase] + S-adenosyl-L-homocysteine + H+
No genes
pyochelinyl-[PchF non-ribosomal peptide synthase] + H2O→pyochelin + H+ + a [PchF non-ribosomal peptide synthase protein]
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information