MetaCyc Pathway: superpathway of melatonin degradation in Cupriavidus basilensis FW507-4G11

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Unspecific monooxygenase:
melatonin + dioxygen + a reduced [NADPH-hemoprotein reductase]→6-hydroxymelatonin + an oxidized [NADPH-hemoprotein reductase] + H2O (EC 1.14.14.1)
RR42_RS19955
Unspecific monooxygenase:
melatonin + dioxygen + a reduced [NADPH-hemoprotein reductase]→N-acetyl-serotonin + formaldehyde + an oxidized [NADPH-hemoprotein reductase] + H2O (EC 1.14.14.1)
RR42_RS19955
melatonin + H2O→5-methoxytryptamine + acetate
No genes
melatonin + 2 hydrogen peroxide→N1-acetyl-N2-formyl-5-methoxykynuramine + 2 H2O
No genes
Aryl sulfotransferase:
6-hydroxymelatonin + 3'-phosphoadenylyl-sulfate→6-sulfatoxymelatonin + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Aryl sulfotransferase:
N-acetyl-serotonin + 3'-phosphoadenylyl-sulfate→N-acetyl-serotonin sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Glucuronosyltransferase:
N-acetyl-serotonin + UDP-α-D-glucuronate→N-acetyl-serotonin glucuronide + H+ + UDP (EC 2.4.1.17)
No genes
Monoamine oxidase:
5-methoxytryptamine + dioxygen + H2O→5-methoxyindoleacetaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
RR42_RS24620
RR42_RS24630
RR42_RS24640
N1-acetyl-N2-formyl-5-methoxykynuramine + H2O→N-acetyl-5-methoxykynurenamine + formate + H+
No genes
5-methoxyindoleacetaldehyde + an oxidized electron carrier + H2O→5-methoxyindole acetate + a reduced two electron carrier + H+
No genes
5-methoxyindoleacetaldehyde + a reduced two electron carrier→5-methoxytryptophol + an oxidized electron carrier
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information