MetaCyc Pathway: peptidoglycan biosynthesis III (mycobacteria) in Cupriavidus basilensis FW507-4G11

Add experiment(s):


D-alanine--D-alanine ligase:
2 D-alanine + ATP→D-alanyl-D-alanine + ADP + H+ + phosphate (EC 6.3.2.4)
RR42_RS18065
Glutamate racemase:
L-glutamate→D-glutamate (EC 5.1.1.3)
RR42_RS13910
UDP-N-acetylglucosamine 1-carboxyvinyltransferase:
UDP-N-acetyl-α-D-glucosamine + phosphoenolpyruvate→UDP-N-acetyl-α-D-glucosamine-enolpyruvate + phosphate (EC 2.5.1.7)
RR42_RS18925
RR42_RS22240
UDP-N-acetyl-α-D-glucosamine-enolpyruvate + NADPH + H+→UDP-N-acetyl-α-D-muramate + NADP+ (EC 1.3.1.98)
RR42_RS17160
UDP-N-acetylmuramate--L-alanine ligase:
UDP-N-acetyl-α-D-muramate + L-alanine + ATP→UDP-N-acetyl-α-D-muramoyl-L-alanine + ADP + H+ + phosphate (EC 6.3.2.8)
RR42_RS18070
UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase:
UDP-N-acetyl-α-D-muramoyl-L-alanine + D-glutamate + ATP→UDP-N-acetyl-α-D-muramoyl-L-alanyl-D-glutamate + ADP + H+ + phosphate (EC 6.3.2.9)
RR42_RS18085
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase:
UDP-N-acetyl-α-D-muramoyl-L-alanyl-D-glutamate + meso-diaminopimelate + ATP→UDP-MurNAc-L-Ala-γ-D-Glu-meso-DAP + ADP + H+ + phosphate (EC 6.3.2.13)
RR42_RS18100
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase:
D-alanyl-D-alanine + UDP-MurNAc-L-Ala-γ-D-Glu-meso-DAP + ATP→UDP-MurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala-D-Ala + ADP + H+ + phosphate (EC 6.3.2.10)
RR42_RS18095
Phospho-N-acetylmuramoyl-pentapeptide-transferase:
UDP-MurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala-D-Ala + trans,octacis-decaprenyl phosphate→Dec-PP-MurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala-D-Ala + UMP (EC 2.7.8.13)
RR42_RS18090
acetylglucosaminyltransferase:
Dec-PP-MurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala-D-Ala + UDP-N-acetyl-α-D-glucosamine→Dec-PP-[β-D-GlcNAc-(1→4)]-MurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala-D-Ala + H+ + UDP (EC 2.4.1.227)
RR42_RS18075
Dec-PP-[β-D-GlcNAc-(1→4)]-MurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala-D-Ala[in] + H+[out]→Dec-PP-[β-D-GlcNAc-(1→4)]-MurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala-D-Ala[out] + H+[in]
No genes
2 Dec-PP-[β-D-GlcNAc-(1→4)]-MurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala-D-Ala→a nascent peptidoglycan dimer (mycobacteria) + mono-trans,octa-cis-decaprenyl diphosphate + H+
No genes
Peptidoglycan glycosyltransferase:
Dec-PP-[β-D-GlcNAc-(1→4)]-MurNAc-L-Ala-γ-D-Glu-meso-DAP-D-Ala-D-Ala + a nascent peptidoglycan (mycobacteria)→a nascent peptidoglycan (mycobacteria) + mono-trans,octa-cis-decaprenyl diphosphate (EC 2.4.1.129)
RR42_RS03775
RR42_RS16540
RR42_RS18105
RR42_RS19040
RR42_RS20345
RR42_RS22420
RR42_RS34290
a nascent peptidoglycan (mycobacteria) + a peptidoglycan internal segment (mycobacteria) + 3 H2O→4 D-alanine + a peptidoglycan with L,D cross-links (mycobacteria)
No genes
a nascent peptidoglycan (mycobacteria) + a peptidoglycan internal segment (mycobacteria) + 3 H2O→4 D-alanine + a peptidoglycan with D,D cross-links (mycobacteria)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information