MetaCyc Pathway: noradrenaline and adrenaline degradation in Cupriavidus basilensis FW507-4G11

MetaCyc Pathway: noradrenaline and adrenaline degradation in Cupriavidus basilensis FW507-4G11

Catechol O-methyltransferase:
(R)-noradrenaline + S-adenosyl-L-methionine→L-normetanephrine + S-adenosyl-L-homocysteine + H⁺ (EC 2.1.1.6)

No genes

Monoamine oxidase:
(R)-noradrenaline + dioxygen + H₂O→3,4-dihydroxyphenylglycolaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)

Phenylethanolamine N-methyltransferase:
(R)-noradrenaline + S-adenosyl-L-methionine→(R)-adrenaline + S-adenosyl-L-homocysteine + H⁺ (EC 2.1.1.28)

No genes

Monoamine oxidase:
(R)-adrenaline + dioxygen + H₂O→3,4-dihydroxyphenylglycolaldehyde + hydrogen peroxide + methylamine (EC 1.4.3.4)

Catechol O-methyltransferase:
(R)-adrenaline + S-adenosyl-L-methionine→metanephrine + S-adenosyl-L-homocysteine + H⁺ (EC 2.1.1.6)

No genes

Monoamine oxidase:
L-normetanephrine + dioxygen + H₂O→3-methoxy-4-hydroxyphenylglycolaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)

Alcohol dehydrogenase (in reverse):
3,4-dihydroxyphenylglycolaldehyde + NADH + H⁺→(R)-3,4-dihydroxyphenylglycol + NAD⁺ (EC 1.1.1.1)

Aldehyde dehydrogenase (NAD(+)):
3,4-dihydroxyphenylglycolaldehyde + NAD⁺ + H₂O→3,4-dihydroxymandelate + NADH + 2 H⁺ (EC 1.2.1.3)

Monoamine oxidase:
metanephrine + dioxygen + H₂O→3-methoxy-4-hydroxyphenylglycolaldehyde + hydrogen peroxide + methylamine (EC 1.4.3.4)

Catechol O-methyltransferase:
(R)-3,4-dihydroxyphenylglycol + S-adenosyl-L-methionine→3-methoxy-4-hydroxyphenylglycol + S-adenosyl-L-homocysteine + H⁺ (EC 2.1.1.6)

No genes

Catechol O-methyltransferase:
3,4-dihydroxymandelate + S-adenosyl-L-methionine→vanillylmandelate + S-adenosyl-L-homocysteine + H⁺ (EC 2.1.1.6)

No genes

Alcohol dehydrogenase:
3-methoxy-4-hydroxyphenylglycol + NAD⁺→3-methoxy-4-hydroxyphenylglycolaldehyde + NADH + H⁺ (EC 1.1.1.1)

Aldehyde dehydrogenase (NAD(+)):
3-methoxy-4-hydroxyphenylglycolaldehyde + NAD⁺ + H₂O→vanillylmandelate + NADH + 2 H⁺ (EC 1.2.1.3)

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information