MetaCyc Pathway: serotonin degradation in Cupriavidus basilensis FW507-4G11

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Aryl sulfotransferase:
serotonin + 3'-phosphoadenylyl-sulfate→serotonin O-sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Monoamine oxidase:
serotonin + dioxygen + H2O→5-hydroxyindole acetaldehyde + ammonium + hydrogen peroxide (EC 1.4.3.4)
RR42_RS24620
RR42_RS24630
RR42_RS24640
5-hydroxyindole acetaldehyde + L-cysteine→5-hydroxyindole thiazolidine carboxylate + H+ + H2O (spontaneous)
No genes
Aldehyde dehydrogenase (NAD(+)):
5-hydroxyindole acetaldehyde + NAD+ + H2O→5-hydroxyindole acetate + NADH + 2 H+ (EC 1.2.1.3)
RR42_RS01275
RR42_RS04280
RR42_RS11360
RR42_RS13660
RR42_RS18500
RR42_RS21485
RR42_RS23750
RR42_RS24065
RR42_RS24390
RR42_RS24705
RR42_RS24840
RR42_RS25005
RR42_RS25010
RR42_RS26255
RR42_RS27350
RR42_RS27780
RR42_RS29955
RR42_RS32140
RR42_RS34255
Alcohol dehydrogenase (in reverse):
5-hydroxyindole acetaldehyde + NADH + H+→5-hydroxytryptophol + NAD+ (EC 1.1.1.1)
RR42_RS09745
RR42_RS10210
RR42_RS10545
RR42_RS11005
RR42_RS18350
RR42_RS24070
RR42_RS24560
RR42_RS25355
RR42_RS25775
RR42_RS28650
RR42_RS32920
RR42_RS34260
RR42_RS34620
RR42_RS36940
Aryl sulfotransferase:
5-hydroxytryptophol + 3'-phosphoadenylyl-sulfate→5-hydroxytryptophol sulfate + adenosine 3',5'-bisphosphate + H+ (EC 2.8.2.1)
No genes
Glucuronosyltransferase:
5-hydroxytryptophol + UDP-α-D-glucuronate→5-hydroxytryptophol glucuronide + H+ + UDP (EC 2.4.1.17)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information