MetaCyc Pathway: superpathway of L-cysteine biosynthesis (fungi) in Cupriavidus basilensis FW507-4G11

Add experiment(s):


Homoserine O-acetyltransferase:
L-homoserine + acetyl-CoA→O-acetyl-L-homoserine + coenzyme A (EC 2.3.1.31)
RR42_RS01160
O-acetylhomoserine aminocarboxypropyltransferase:
O-acetyl-L-homoserine + hydrogen sulfide→L-homocysteine + acetate + H+ (EC 2.5.1.49)
RR42_RS06465
RR42_RS14320
RR42_RS32610
Cystathionine beta-synthase:
L-homocysteine + L-serine→L-cystathionine + H2O (EC 4.2.1.22)
No genes
Cysteine-S-conjugate beta-lyase:
L-cystathionine + H2O→L-homocysteine + ammonium + pyruvate (EC 4.4.1.13)
No genes
Cystathionine gamma-lyase:
L-cystathionine + H2O→L-cysteine + 2-oxobutanoate + ammonium (EC 4.4.1.1)
No genes
Cystathionine gamma-synthase:
L-cysteine + O-succinyl-L-homoserine→L-cystathionine + H+ + succinate (EC 2.5.1.48)
RR42_RS06465
RR42_RS14320
RR42_RS32610

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information