MetaCyc Pathway: superpathway of adenosylcobalamin salvage from cobinamide II in Cupriavidus basilensis FW507-4G11

MetaCyc Pathway: superpathway of adenosylcobalamin salvage from cobinamide II in Cupriavidus basilensis FW507-4G11

Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase:
5,6-dimethylbenzimidazole + β-nicotinate D-ribonucleotide→α-ribazole 5'-phosphate + nicotinate + H⁺ (EC 2.4.2.21)

Cob(I)yrinic acid a,c-diamide adenosyltransferase:
cob(II)inamide + a [corrinoid adenosyltransferase]→[corrinoid adenosyltranferase]-cob(II)inamide (EC 2.5.1.17)

Cob(I)yrinic acid a,c-diamide adenosyltransferase:
2 [corrinoid adenosyltranferase]-cob(II)inamide + a [reduced flavoprotein]→2 [corrinoid adenosyltranferase]-cob(I)inamide + an [oxidized flavoprotein] + 2 H⁺ (spontaneous) (EC 2.5.1.17)

Cob(I)yrinic acid a,c-diamide adenosyltransferase:
2 [corrinoid adenosyltranferase]-cob(I)inamide + 2 ATP + 2 H⁺→2 adenosylcobinamide + 2 a [corrinoid adenosyltransferase] + 2 triphosphate (EC 2.5.1.17)

Adenosylcobinamide hydrolase:
adenosylcobinamide + H₂O→adenosylcobyrate + (R)-1-aminopropan-2-ol (EC 3.5.1.90)

No genes

Adenosylcobinamide-phosphate synthase:
adenosylcobyrate + (R)-1-amino-2-propanol O-2-phosphate + ATP→adenosyl-cobinamide phosphate + ADP + H⁺ + phosphate (EC 6.3.1.10)

Adenosylcobinamide-phosphate guanylyltransferase:
adenosyl-cobinamide phosphate + GTP + H⁺→adenosylcobinamide-GDP + diphosphate (EC 2.7.7.62)

Adenosylcobinamide-GDP ribazoletransferase:
adenosylcobinamide-GDP + α-ribazole 5'-phosphate→adenosylcobalamin 5'-phosphate + GMP + H⁺ (EC 2.7.8.26)

Alpha-ribazole phosphatase:
adenosylcobalamin 5'-phosphate + H₂O→adenosylcobalamin + phosphate (EC 3.1.3.73)

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information