MetaCyc Pathway: superpathway of CMP-sialic acids biosynthesis in Cupriavidus basilensis FW507-4G11

Add experiment(s):


Mannokinase:
D-mannopyranose + ATP→D-mannopyranose 6-phosphate + ADP + H+ (EC 2.7.1.7)
No genes
UDP-N-acetyl-α-D-glucosamine + acetyl-CoA→4-O-acetyl-UDP-N-acetylglucosamine + coenzyme A
No genes
UDP-N-acetyl-α-D-glucosamine + H2O→N-acetyl-α-D-mannosamine + H+ + UDP (EC 3.2.1.183)
No genes
N-acetylneuraminate synthase:
N-acetyl-D-mannosamine + phosphoenolpyruvate + H2O→N-acetyl-β-neuraminate + phosphate (EC 2.5.1.56)
RR42_RS15775
N-acylmannosamine kinase:
N-acetyl-D-mannosamine + ATP→N-acetyl-D-mannosamine 6-phosphate + ADP + H+ (EC 2.7.1.60)
No genes
4-O-acetyl-UDP-N-acetylglucosamine + H2O→4-O-acetyl-N-acetylmannosamine + H+ + UDP
No genes
D-mannopyranose 6-phosphate + phosphoenolpyruvate + H2O→3-deoxy-D-glycero-D-galacto-nononate 9-phosphate + phosphate (EC 2.5.1.132)
No genes
4-O-acetyl-N-acetylmannosamine + phosphoenolpyruvate + H2O→N-acetyl-7-O-acetylneuraminate + phosphate
No genes
N-acylneuraminate-9-phosphate synthase:
N-acetyl-D-mannosamine 6-phosphate + phosphoenolpyruvate + H2O→N-acetyl-β-neuraminate 9-phosphate + phosphate (EC 2.5.1.57)
No genes
3-deoxy-D-glycero-D-galacto-nononate 9-phosphate + H2O→3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate + phosphate (EC 3.1.3.103)
No genes
N-acetyl-7-O-acetylneuraminate + CTP→CMP-N-acetyl-7-O-acetyl-β-neuraminate + diphosphate
No genes
N-acylneuraminate-9-phosphatase:
N-acetyl-β-neuraminate 9-phosphate + H2O→N-acetyl-β-neuraminate + phosphate (EC 3.1.3.29)
No genes
3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate + CTP→CMP-3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate + diphosphate (EC 2.7.7.92)
No genes
N-acylneuraminate cytidylyltransferase:
N-acetyl-β-neuraminate + CTP→CMP-N-acetyl-β-neuraminate + diphosphate (EC 2.7.7.43)
No genes
CMP-N-acetylneuraminate monooxygenase:
CMP-N-acetyl-β-neuraminate + 2 a ferrocytochrome b5 + dioxygen + 2 H+→CMP-N-glycoloyl-β-neuraminate + 2 a ferricytochrome b5 + H2O (EC 1.14.18.2)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information