MetaCyc Pathway: chlorosalicylate degradation in Cupriavidus basilensis FW507-4G11

Add experiment(s):


Salicylate 1-monooxygenase:
4-chlorosalicylate + NADH + dioxygen + 2 H+→4-chlorocatechol + CO2 + NAD+ + H2O (EC 1.14.13.1)
RR42_RS03265
RR42_RS06410
RR42_RS14855
RR42_RS21625
RR42_RS22480
RR42_RS24050
RR42_RS24155
RR42_RS24285
RR42_RS25760
RR42_RS30505
Salicylate 1-monooxygenase:
5-chlorosalicylate + NADH + dioxygen + 2 H+→4-chlorocatechol + CO2 + NAD+ + H2O (EC 1.14.13.1)
RR42_RS03265
RR42_RS06410
RR42_RS14855
RR42_RS21625
RR42_RS22480
RR42_RS24050
RR42_RS24155
RR42_RS24285
RR42_RS25760
RR42_RS30505
4-chlorocatechol + dioxygen→3-chloro-cis,cis-muconate + 2 H+ (EC 1.13.11.M6)
No genes
Chloromuconate cycloisomerase (in reverse):
3-chloro-cis,cis-muconate + H+→(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate (EC 5.5.1.7)
No genes
(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate→protoanemonin + CO2 + chloride
No genes
(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate + H2O→2-maleylacetate + chloride + 2 H+
No genes
Maleylacetate reductase (in reverse):
2-maleylacetate + NAD(P)H + H+→3-oxoadipate + NAD(P)+ (EC 1.3.1.32)
RR42_RS32920
RR42_RS34620

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information