MetaCyc Pathway: serotonin and melatonin biosynthesis in Cupriavidus basilensis FW507-4G11

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Tryptophan 5-monooxygenase:
L-tryptophan + dioxygen + 5,6,7,8-tetrahydrobiopterin→5-hydroxy-L-tryptophan + a 4a-hydroxytetrahydrobiopterin (EC 1.14.16.4)
No genes
Aromatic-L-amino-acid decarboxylase:
5-hydroxy-L-tryptophan + H+→serotonin + CO2 (EC 4.1.1.28)
RR42_RS26695
Aralkylamine N-acetyltransferase:
serotonin + acetyl-CoA→N-acetyl-serotonin + coenzyme A + H+ (EC 2.3.1.87)
No genes
Acetylserotonin O-methyltransferase:
N-acetyl-serotonin + S-adenosyl-L-methionine→melatonin + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.4)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information