MetaCyc Pathway: hypusine biosynthesis in Cupriavidus basilensis FW507-4G11

Add experiment(s):


Homospermidine synthase:
spermidine + NAD+→(E)-(4-aminobutylidene)(3-aminopropyl)amine + NADH + H+ (EC 2.5.1.44; 2.5.1.45; 2.5.1.46)
RR42_RS31005
Deoxyhypusine synthase:
(E)-(4-aminobutylidene)(3-aminopropyl)amine + a [deoxyhypusine synthase]-L-lysine→a [deoxyhypusine synthase]-N-(4-aminobutylidene)-lysine + propane-1,3-diamine (EC 2.5.1.46)
No genes
Deoxyhypusine synthase:
a [deoxyhypusine synthase]-N-(4-aminobutylidene)-lysine + an [eIF5A-precursor]-lysine→an [eIF5A-precursor]-N-(4-aminobutylidene)-lysine + a [deoxyhypusine synthase]-L-lysine + H+ (EC 2.5.1.46)
No genes
Deoxyhypusine synthase:
an [eIF5A-precursor]-N-(4-aminobutylidene)-lysine + NADH + H+→an [eIF5A-precursor]-deoxyhypusine + NAD+ (EC 2.5.1.46)
No genes
Deoxyhypusine monooxygenase:
an [eIF5A-precursor]-deoxyhypusine + a reduced two electron carrier + dioxygen→an [eIF5A]-hypusine + an oxidized electron carrier + H2O (EC 1.14.99.29)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information