MetaCyc Pathway: bacillibactin biosynthesis in Cupriavidus basilensis FW507-4G11

Add experiment(s):


Isochorismate synthase:
chorismate→isochorismate
(EC 5.4.4.2)
No genes
Alanine--tRNA ligase:
glycine + ATP→(glycyl)adenylate + diphosphate
(EC 6.1.1.7; 6.2.1.66)
RR42_RS15150
Threonine--tRNA ligase:
L-threonine + ATP + H+→(L-threonyl)adenylate + diphosphate
(EC 6.1.1.3; 6.1.1.9; 6.2.1.70)
RR42_RS06600
RR42_RS15095
Isochorismatase:
isochorismate + H2O→(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate
(EC 3.3.2.1)
RR42_RS13740
RR42_RS23110
RR42_RS33815
(L-threonyl)adenylate + a [DhbF non-ribosomal peptide synthase]→an L-threonyl-[DhbF non-ribosomal peptide synthase] + AMP + H+ (EC 6.2.1.70)
No genes
(glycyl)adenylate + a [DhbF non-ribosomal peptide synthase]→a glycyl-[DhbF non-ribosomal peptide synthase] + AMP (EC 6.2.1.66)
No genes
2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase:
(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD+→2,3-dihydroxybenzoate + NADH + H+
(EC 1.3.1.28)
No genes
2,3-dihydroxybenzoate + ATP + H+→(2,3-dihydroxybenzoyl)adenylate + diphosphate (EC 6.2.1.71)
No genes
(2,3-dihydroxybenzoyl)adenylate + a holo-[DhbB aryl-carrier protein]→a 2,3-dihydroxybenzoyl-[DhbB aryl-carrier protein] + AMP + H+ (EC 6.2.1.71)
No genes
a 2,3-dihydroxybenzoyl-[DhbB aryl-carrier protein] + a glycyl-[DhbF non-ribosomal peptide synthase]→a 2,3-dihydroxybenzoyl-glycyl-[DhbF non-ribosomal peptide synthase] + a holo-[DhbB aryl-carrier protein] + H+
No genes
a 2,3-dihydroxybenzoyl-glycyl-[DhbF non-ribosomal peptide synthase] + an L-threonyl-[DhbF non-ribosomal peptide synthase]→a 2,3-dihydroxybenzoyl-glycyl-L-threonyl-[DhbF non-ribosomal peptide synthase] + a [DhbF non-ribosomal peptide synthase] + H+
No genes
3 a 2,3-dihydroxybenzoyl-glycyl-L-threonyl-[DhbF non-ribosomal peptide synthase]→bacillibactin + 3 a [DhbF non-ribosomal peptide synthase]
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information