MetaCyc Pathway: fosfomycin biosynthesis in Cupriavidus basilensis FW507-4G11

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Phosphoenolpyruvate mutase:
phosphoenolpyruvate + H+→3-phosphonopyruvate (EC 5.4.2.9)
RR42_RS22445
Phosphonopyruvate decarboxylase:
3-phosphonopyruvate + H+→phosphonoacetaldehyde + CO2 (EC 4.1.1.82)
RR42_RS22450
phosphonoacetaldehyde + NADH + H+→2-hydroxyethylphosphonate + NAD+ (EC 1.1.1.309)
No genes
2-hydroxyethylphosphonate + CTP→cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + diphosphate (EC 2.7.7.104)
No genes
cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} + a reduced two electron carrier + 2 S-adenosyl-L-methionine→cytidine 5'-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate} + S-adenosyl-L-homocysteine + an oxidized electron carrier + 5'-deoxyadenosine + L-methionine + 2 H+ (EC 2.1.1.308)
No genes
cytidine 5'-{[hydroxy(2-hydroxypropyl)phosphonoyl]phosphate} + H2O→(S)-2-hydroxypropylphosphonate + CMP + H+
No genes
(S)-2-hydroxypropylphosphonate + hydrogen peroxide→fosfomycin + 2 H2O (EC 1.11.1.23)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information