MetaCyc Pathway: 2-methylcitrate cycle II in Cupriavidus basilensis FW507-4G11

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Propionate--CoA ligase:
propanoate + ATP + coenzyme A→propanoyl-CoA + AMP + diphosphate (EC 6.2.1.17)
RR42_RS13560
RR42_RS13880
2-methylcitrate synthase:
propanoyl-CoA + oxaloacetate + H2O→(2S,3S)-2-methylcitrate + coenzyme A + H+ (EC 2.3.3.5)
RR42_RS11265
RR42_RS14475
(2S,3S)-2-methylcitrate→2-methyl-trans-aconitate + H2O (EC 4.2.1.117)
RR42_RS11270
2-methyl-trans-aconitate→cis-2-methylaconitate
No genes
2-methylisocitrate dehydratase (in reverse):
cis-2-methylaconitate + H2O→(2R,3S)-2-methylisocitrate (EC 4.2.1.99)
RR42_RS11270
RR42_RS14490
RR42_RS23515
Methylisocitrate lyase:
(2R,3S)-2-methylisocitrate→pyruvate + succinate (EC 4.1.3.30)
RR42_RS11260
RR42_RS22765

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information