MetaCyc Pathway: clavulanate biosynthesis in Cupriavidus basilensis FW507-4G11

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N(2)-(2-carboxyethyl)arginine synthase:
L-arginine + D-glyceraldehyde 3-phosphate→L-N2-(2-carboxyethyl)arginine + 2 H+ + phosphate (EC 2.5.1.66)
No genes
(Carboxyethyl)arginine beta-lactam-synthase:
L-N2-(2-carboxyethyl)arginine + ATP→deoxyamidinoproclavaminate + AMP + diphosphate (EC 6.3.3.4)
No genes
Clavaminate synthase:
deoxyamidinoproclavaminate + 2-oxoglutarate + dioxygen→amidinoproclavaminate + CO2 + succinate (EC 1.14.11.21)
No genes
Proclavaminate amidinohydrolase:
amidinoproclavaminate + H2O→proclavaminate + urea (EC 3.5.3.22)
No genes
Clavaminate synthase:
proclavaminate + 2-oxoglutarate + dioxygen→dihydroclavaminate + CO2 + succinate + H2O (EC 1.14.11.21)
No genes
Clavaminate synthase:
dihydroclavaminate + 2-oxoglutarate + dioxygen→clavaminate + CO2 + succinate + H2O (EC 1.14.11.21)
No genes
clavaminate + ATP + glycine→N-glycylclavaminate + ADP + H+ + phosphate
No genes
N-glycylclavaminate + acetyl-CoA→N-acetylglycylclavaminate + coenzyme A + H+
No genes
N-acetylglycylclavaminate→clavaldehyde
No genes
clavaldehyde + NADPH + H+→clavulanate + NADP+
RR42_RS36075

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information