MetaCyc Pathway: 4-nitrotoluene degradation II in Cupriavidus basilensis FW507-4G11

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4-nitrotoluene + 2 NADPH + 2 H+→4-hydroxylaminotoluene + 2 NADP+ + H2O
No genes
(Hydroxyamino)benzene mutase:
4-hydroxylaminotoluene→2-amino-5-methylphenol (EC 5.4.4.1)
No genes
2-amino-5-methylphenol + dioxygen→(2Z,4E)-2-amino-5-methyl-muconate semialdehyde + H+ (EC 1.13.11.74)
No genes
Aminomuconate-semialdehyde dehydrogenase:
(2Z,4E)-2-amino-5-methyl-muconate semialdehyde + NAD+ + H2O→(2Z,4E)-2-amino-5-methyl-muconate + NADH + 2 H+ (EC 1.2.1.32)
RR42_RS05110
RR42_RS32650
2-aminomuconate deaminase:
(2Z,4E)-2-amino-5-methyl-muconate + H+ + H2O→(E)-5-methyl-2-oxo-3-hex-3-enedioate + ammonium (EC 3.5.99.5)
RR42_RS05085
4-oxalocrotonate decarboxylase:
(E)-5-methyl-2-oxo-3-hex-3-enedioate + H+→(4E)-2-oxo-hex-4-enoate + CO2 (EC 4.1.1.77)
RR42_RS05105
RR42_RS31850
RR42_RS32640
RR42_RS32645
(4E)-2-oxo-hex-4-enoate + an oxidized electron carrier + H2O→(3Z)-4-hydroxy-2-oxohexenoate + a reduced two electron carrier
No genes
(3Z)-4-hydroxy-2-oxohexenoate + a reduced two electron carrier→(S)-4-hydroxy-2-oxohexanoate + an oxidized electron carrier
No genes
(S)-4-hydroxy-2-oxohexanoate→1-propanal + pyruvate (EC 4.1.3.43)
RR42_RS31860

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information