MetaCyc Pathway: factor 430 biosynthesis in Cupriavidus basilensis FW507-4G11

Add experiment(s):


Uroporphyrinogen-III C-methyltransferase:
uroporphyrinogen-III + S-adenosyl-L-methionine→precorrin-1 + S-adenosyl-L-homocysteine + H+ (EC 2.1.1.107)
RR42_RS15895
RR42_RS16245
Uroporphyrinogen-III C-methyltransferase:
precorrin-1 + S-adenosyl-L-methionine→precorrin-2 + S-adenosyl-L-homocysteine (EC 2.1.1.107)
RR42_RS15895
RR42_RS16245
Precorrin-2 dehydrogenase:
precorrin-2 + NAD+→sirohydrochlorin + NADH + 2 H+ (EC 1.3.1.76)
RR42_RS16240
RR42_RS16245
sirohydrochlorin + Ni2+→Ni-sirohydrochlorin + 2 H+ (EC 4.99.1.11)
No genes
Ni-sirohydrochlorin + 2 ATP + 2 L-glutamine + 2 H2O→Ni-sirohydrochlorin a,c-diamide + 2 ADP + 2 L-glutamate + 2 H+ + 2 phosphate (EC 6.3.5.12)
No genes
Ni-sirohydrochlorin a,c-diamide + ATP + 3 a reduced two electron carrier + H2O→15,173-seco-F430-173-acid + ADP + 3 an oxidized electron carrier + phosphate (EC 6.3.3.7)
No genes
15,173-seco-F430-173-acid + ATP→oxidized factor 430 + ADP + phosphate (EC 6.4.1.9)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information