MetaCyc Pathway: tetrapyrrole biosynthesis I (from glutamate) in Cupriavidus basilensis FW507-4G11

Add experiment(s):


Glutamate--tRNA ligase:
L-glutamate + ATP + a tRNAglu→an L-glutamyl-[tRNAGlu] + AMP + diphosphate (EC 6.1.1.17)
RR42_RS13355
Glutamyl-tRNA reductase (in reverse):
an L-glutamyl-[tRNAGlu] + NADPH + H+→(S)-4-amino-5-oxopentanoate + a tRNAglu + NADP+ (EC 1.2.1.70)
RR42_RS18465
Glutamate-1-semialdehyde 2,1-aminomutase:
(S)-4-amino-5-oxopentanoate→5-aminolevulinate (EC 5.4.3.8)
RR42_RS04235
RR42_RS15790
Porphobilinogen synthase:
2 5-aminolevulinate→porphobilinogen + H+ + 2 H2O (EC 4.2.1.24)
RR42_RS19100
Hydroxymethylbilane synthase:
4 porphobilinogen + H2O→preuroporphyrinogen + 4 ammonium (EC 2.5.1.61)
RR42_RS15900
Uroporphyrinogen-III synthase:
preuroporphyrinogen→uroporphyrinogen-III + H2O (EC 4.2.1.75)
RR42_RS15895

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information