MetaCyc Pathway: lupulone and humulone biosynthesis in Cupriavidus basilensis FW507-4G11

Add experiment(s):


Acetate--CoA ligase:
3-methylbutanoate + ATP + coenzyme A→3-methylbutanoyl-CoA + AMP + diphosphate (EC 6.2.1.1)
RR42_RS06210
RR42_RS10650
RR42_RS13880
RR42_RS22715
RR42_RS24890
RR42_RS29035
Phloroisovalerophenone synthase:
3-methylbutanoyl-CoA + 3 malonyl-CoA + 3 H+→phlorisovalerophenone + 3 CO2 + 4 coenzyme A (EC 2.3.1.156)
No genes
phlorisovalerophenone + prenyl diphosphate→4-prenylphlorisovalerophenone + diphosphate + H+ (EC 2.5.1.136)
No genes
4-prenylphlorisovalerophenone + prenyl diphosphate→deoxyhumulone + diphosphate (EC 2.5.1.137)
No genes
deoxyhumulone + prenyl diphosphate→lupulone + diphosphate (EC 2.5.1.137)
No genes
deoxyhumulone + a reduced two electron carrier + dioxygen→humulone + an oxidized electron carrier + H2O (EC 1.14.99.M4)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information