MetaCyc Pathway: sphingolipid biosynthesis (plants) in Cupriavidus basilensis FW507-4G11

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Serine C-palmitoyltransferase:
palmitoyl-CoA + L-serine + H+→3-dehydrosphinganine + CO2 + coenzyme A (EC 2.3.1.50)
No genes
3-dehydrosphinganine reductase (in reverse):
3-dehydrosphinganine + NADPH + H+→sphinganine + NADP+ (EC 1.1.1.102)
No genes
Sphingosine N-acyltransferase:
sphinganine + an acyl-CoA→a dihydroceramide + coenzyme A + H+ (EC 2.3.1.24)
No genes
sphinganine + 2 a ferrocytochrome b5 + dioxygen + 2 H+→phytosphingosine + 2 a ferricytochrome b5 + H2O (EC 1.14.18.5)
No genes
Sphinganine kinase:
sphinganine + ATP→sphinganine 1-phosphate + ADP + H+ (EC 2.7.1.91)
No genes
a dihydroceramide + 2 a ferrocytochrome b5 + dioxygen + 2 H+→a (C18)-phytoceramide + 2 a ferricytochrome b5 + H2O (EC 1.14.18.5)
No genes
Ceramide glucosyltransferase:
a dihydroceramide + UDP-α-D-glucose→a β-D-glucosyl-N-acylsphinganine + H+ + UDP (EC 2.4.1.80)
RR42_RS35290
a dihydroceramide + a 1-phosphatidyl-1D-myo-inositol→an inositol phosphodihydroceramide + a 1,2-diacyl-sn-glycerol
No genes
a dihydroceramide + 2 a ferrocytochrome b5 + dioxygen + 2 H+→a (2'R)-2'-hydroxydihydroceramide + 2 a ferricytochrome b5 + H2O (EC 1.14.18.7)
No genes
Ceramide kinase:
a dihydroceramide + ATP→a dihydroceramide 1-phosphate + ADP + H+ (EC 2.7.1.138)
No genes
a dihydroceramide + a sterol 3-glucoside→a β-D-glucosyl-N-acylsphinganine + a sterol
No genes
a β-D-glucosyl-N-acylsphinganine + 2 a ferrocytochrome b5 + dioxygen + 2 H+→a β-D-glucosyl-N-acylsphingosine + 2 a ferricytochrome b5 + 2 H2O (EC 1.14.19.17)
No genes
a (C18)-phytoceramide + 2 a ferrocytochrome b5 + dioxygen + 2 H+→an (8E)-4-hydroxysphing-8-enine ceramide + 2 a ferricytochrome b5 + 2 H2O (EC 1.14.19.29)
No genes

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information