MetaCyc Pathway: superpathway of coenzyme A biosynthesis II (plants) in Cupriavidus basilensis FW507-4G11

MetaCyc Pathway: superpathway of coenzyme A biosynthesis II (plants) in Cupriavidus basilensis FW507-4G11

3-methyl-2-oxobutanoate hydroxymethyltransferase:
3-methyl-2-oxobutanoate + a 5,10-methylenetetrahydrofolate + H₂O→2-dehydropantoate + a tetrahydrofolate (EC 2.1.2.11)

Propionate--CoA ligase:
propanoate + ATP + coenzyme A→propanoyl-CoA + AMP + diphosphate (EC 6.2.1.17)

2-dehydropantoate 2-reductase (in reverse):
2-dehydropantoate + NADPH + H⁺→(R)-pantoate + NADP⁺ (EC 1.1.1.169)

propanoyl-CoA + an oxidized electron-transfer flavoprotein + H⁺→acryloyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.1)

acryloyl-CoA + H₂O→3-hydroxypropanoyl-CoA (EC 4.2.1.116)

No genes

3-hydroxyisobutyryl-CoA hydrolase:
3-hydroxypropanoyl-CoA + H₂O→3-hydroxypropanoate + coenzyme A + H⁺ (EC 3.1.2.4)

3-hydroxypropionate dehydrogenase:
3-hydroxypropanoate + NAD⁺→3-oxopropanoate + NADH + H⁺ (EC 1.1.1.59)

Beta-alanine--pyruvate transaminase:
3-oxopropanoate + L-alanine→β-alanine + pyruvate (EC 2.6.1.18)

Pantoate--beta-alanine ligase:
β-alanine + (R)-pantoate + ATP→(R)-pantothenate + AMP + diphosphate + H⁺ (EC 6.3.2.1)

Pantothenate kinase:
(R)-pantothenate + ATP→(R)-4'-phosphopantothenate + ADP + H⁺ (EC 2.7.1.33)

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information