Aspartate kinase:
L-aspartate + ATP→L-aspartyl-4-phosphate + ADP (EC 2.7.2.4) |
| RR42_RS06370 |
Aspartate-semialdehyde dehydrogenase (in reverse):
L-aspartyl-4-phosphate + NADPH + H+→L-aspartate 4-semialdehyde + NADP+ + phosphate (EC 1.2.1.11) |
| RR42_RS14380 |
| L-aspartate 4-semialdehyde + pyruvate→(2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H+ + H2O (EC 4.3.3.7) |
| RR42_RS04230 |
| RR42_RS05135 |
| RR42_RS06250 |
| RR42_RS17475 |
| RR42_RS33075 |
| (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+→(S)-2,3,4,5-tetrahydrodipicolinate + NAD(P)+ + H2O (EC 1.17.1.8) |
| RR42_RS17550 |
| RR42_RS18515 |
| (S)-2,3,4,5-tetrahydrodipicolinate + H+ + H2O→L-α-amino-ε-keto-pimelate (spontaneous) |
| No genes |
Diaminopimelate dehydrogenase (in reverse):
L-α-amino-ε-keto-pimelate + ammonium + NADPH + H+→meso-diaminopimelate + NADP+ + H2O (EC 1.4.1.16) |
| No genes |
Diaminopimelate decarboxylase:
meso-diaminopimelate + H+→L-lysine + CO2 (EC 4.1.1.20) |
| RR42_RS19050 |
Links:
Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information