MetaCyc Pathway: purine nucleobases degradation I (anaerobic) in Cupriavidus basilensis FW507-4G11

Add experiment(s):


Guanine deaminase:
guanine + H+ + H2O→xanthine + ammonium (EC 3.5.4.3)
RR42_RS05320
RR42_RS07300
purine + an oxidized electron carrier + H2O→hypoxanthine + a reduced two electron carrier (EC 1.17.99.M4)
No genes
hypoxanthine + an oxidized electron carrier + H2O→xanthine + a reduced two electron carrier (EC 1.17.99.M4)
No genes
xanthine + H2O→5-ureidoimidazole-4-carboxylate + H+
No genes
5-ureidoimidazole-4-carboxylate + 2 H+ + H2O→5-aminoimidazole-4-carboxylate + CO2 + ammonium
No genes
5-aminoimidazole-4-carboxylate→CO2 + 4-aminoimidazole
No genes
Aminoimidazolase:
4-aminoimidazole + H+ + H2O→3,5-dihydro-4H-imidazol-4-one + ammonium (EC 3.5.4.8)
No genes
3,5-dihydro-4H-imidazol-4-one + H2O→N-formimino-glycine (spontaneous)
No genes
Glycine formimidoyltransferase (in reverse):
N-formimino-glycine + a tetrahydrofolate→5-formimidoyltetrahydrofolate + glycine (EC 2.1.2.4)
No genes
Formimidoyltetrahydrofolate cyclodeaminase:
5-formimidoyltetrahydrofolate + 2 H+→a 5,10-methenyltetrahydrofolate + ammonium (EC 4.3.1.4)
No genes
Glycine reductase (in reverse):
glycine + H+ + phosphate + a reduced thioredoxin→acetyl phosphate + ammonium + an oxidized thioredoxin + H2O (EC 1.21.4.2)
No genes
Acetate kinase (in reverse):
acetyl phosphate + ADP→acetate + ATP (EC 2.7.2.1; 2.7.2.15)
RR42_RS03800
RR42_RS22745
Methenyltetrahydrofolate cyclohydrolase:
a 5,10-methenyltetrahydrofolate + H2O→an N10-formyltetrahydrofolate + H+ (EC 3.5.4.9)
RR42_RS07345
Formyltetrahydrofolate deformylase:
an N10-formyltetrahydrofolate + H2O→formate + H+ + a tetrahydrofolate (EC 3.5.1.10)
RR42_RS13800
formate + NAD+→CO2 + NADH (EC 1.17.1.9)
RR42_RS03765
RR42_RS15950
RR42_RS15965
RR42_RS18180
RR42_RS31310

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information