MetaCyc Pathway: trans-4-hydroxy-L-proline degradation I in Cupriavidus basilensis FW507-4G11

Add experiment(s):


trans-4-hydroxy-L-proline[in] + an electron-transfer quinone→(3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate[in] + an electron-transfer quinol + H+[in] (EC 1.5.5.3)
No genes
(3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate + H+ + H2O→L-4-hydroxyglutamate semialdehyde (spontaneous)
No genes
L-4-hydroxyglutamate semialdehyde + NAD+ + H2O→erythro-4-hydroxy-L-glutamate + NADH + 2 H+
No genes
4-hydroxyglutamate transaminase:
erythro-4-hydroxy-L-glutamate + 2-oxoglutarate→(4R)-4-hydroxy-2-oxoglutarate + L-glutamate (EC 2.6.1.23)
RR42_RS01570
RR42_RS01590
RR42_RS02275
RR42_RS04985
RR42_RS05770
RR42_RS09190
RR42_RS09965
RR42_RS10785
RR42_RS12545
RR42_RS14560
RR42_RS15580
RR42_RS16470
RR42_RS21340
RR42_RS25980
RR42_RS26005
RR42_RS26015
RR42_RS26185
RR42_RS26625
RR42_RS28185
RR42_RS32165
RR42_RS33140
RR42_RS33805
RR42_RS35305
RR42_RS36780
4-hydroxy-2-oxoglutarate aldolase:
(4R)-4-hydroxy-2-oxoglutarate→glyoxylate + pyruvate (EC 4.1.3.16)
RR42_RS28865

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information