MetaCyc Pathway: L-histidine biosynthesis in Cupriavidus basilensis FW507-4G11

ATP phosphoribosyltransferase (in reverse): 5-phospho-α-D-ribose 1-diphosphate + ATP→1-(5-phospho-β-D-ribosyl)-ATP + diphosphate (EC 2.4.2.17)

RR42_RS13095

RR42_RS18920

Phosphoribosyl-ATP diphosphatase: 1-(5-phospho-β-D-ribosyl)-ATP + H2O→1-(5-phospho-β-D-ribosyl)-AMP + diphosphate + H+ (EC 3.6.1.31)

RR42_RS18875

RR42_RS18880

Phosphoribosyl-AMP cyclohydrolase: 1-(5-phospho-β-D-ribosyl)-AMP + H2O→1-(5-phospho-β-D-ribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide (EC 3.5.4.19)

RR42_RS18875

RR42_RS18880

isomerase: 1-(5-phospho-β-D-ribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide→phosphoribulosylformimino-AICAR-phosphate (EC 5.3.1.16)

RR42_RS18890

phosphoribulosylformimino-AICAR-phosphate + L-glutamine→5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)-glycerol 3-phosphate + L-glutamate + H+ (EC 4.3.2.10)

RR42_RS18885

RR42_RS18895

RR42_RS18900

Imidazoleglycerol-phosphate dehydratase: D-erythro-1-(imidazol-4-yl)-glycerol 3-phosphate→3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O (EC 4.2.1.19)

RR42_RS18905

Histidinol-phosphate transaminase (in reverse): 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate→L-histidinol phosphate + 2-oxoglutarate (EC 2.6.1.9)

RR42_RS04465

RR42_RS18910

Histidinol-phosphatase: L-histidinol phosphate + H2O→histidinol + phosphate (EC 3.1.3.15)

RR42_RS02815

RR42_RS03715

Histidinol dehydrogenase: histidinol + NAD+→histidinal + NADH + H+ (EC 1.1.1.23)

RR42_RS18915

Histidinol dehydrogenase: histidinal + NAD+ + H2O→L-histidine + NADH + 2 H+ (EC 1.1.1.23)

RR42_RS18915

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information