MetaCyc Pathway: superpathway of adenosylcobalamin salvage from cobinamide I in Cupriavidus basilensis FW507-4G11

Add experiment(s):


Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase:
5,6-dimethylbenzimidazole + β-nicotinate D-ribonucleotide→α-ribazole 5'-phosphate + nicotinate + H+ (EC 2.4.2.21)
RR42_RS16120
Cob(I)yrinic acid a,c-diamide adenosyltransferase:
cob(II)inamide + a [corrinoid adenosyltransferase]→[corrinoid adenosyltranferase]-cob(II)inamide (EC 2.5.1.17)
RR42_RS16125
RR42_RS17280
Cob(I)yrinic acid a,c-diamide adenosyltransferase:
2 [corrinoid adenosyltranferase]-cob(II)inamide + a [reduced flavoprotein]→2 [corrinoid adenosyltranferase]-cob(I)inamide + an [oxidized flavoprotein] + 2 H+ (spontaneous) (EC 2.5.1.17)
RR42_RS16125
RR42_RS17280
Cob(I)yrinic acid a,c-diamide adenosyltransferase:
2 [corrinoid adenosyltranferase]-cob(I)inamide + 2 ATP + 2 H+→2 adenosylcobinamide + 2 a [corrinoid adenosyltransferase] + 2 triphosphate (EC 2.5.1.17)
RR42_RS16125
RR42_RS17280
Adenosylcobinamide kinase:
adenosylcobinamide + ATP→adenosyl-cobinamide phosphate + ADP + H+ (EC 2.7.1.156)
RR42_RS16080
Adenosylcobinamide-phosphate guanylyltransferase:
adenosyl-cobinamide phosphate + GTP + H+→adenosylcobinamide-GDP + diphosphate (EC 2.7.7.62)
RR42_RS16080
Adenosylcobinamide-GDP ribazoletransferase:
adenosylcobinamide-GDP + α-ribazole 5'-phosphate→adenosylcobalamin 5'-phosphate + GMP + H+ (EC 2.7.8.26)
RR42_RS16115
Alpha-ribazole phosphatase:
adenosylcobalamin 5'-phosphate + H2O→adenosylcobalamin + phosphate (EC 3.1.3.73)
RR42_RS16110

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information