MetaCyc Pathway: superpathway of coenzyme A biosynthesis III (mammals) in Cupriavidus basilensis FW507-4G11

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Pantothenate kinase:
(R)-pantothenate + ATP→(R)-4'-phosphopantothenate + ADP + H+ (EC 2.7.1.33)
RR42_RS00700
(R)-4'-phosphopantothenate + ATP + L-cysteine→(R)-4'-phosphopantothenoyl-L-cysteine + AMP + diphosphate + H+ (EC 6.3.2.51)
RR42_RS17080
Phosphopantothenoylcysteine decarboxylase:
(R)-4'-phosphopantothenoyl-L-cysteine + H+→4'-phosphopantetheine + CO2 (EC 4.1.1.36)
RR42_RS17080
Pantetheine-phosphate adenylyltransferase:
4'-phosphopantetheine + ATP + H+→3'-dephospho-CoA + diphosphate (EC 2.7.7.3)
RR42_RS01995
Dephospho-CoA kinase:
3'-dephospho-CoA + ATP→coenzyme A + ADP + H+ (EC 2.7.1.24)
RR42_RS17995

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information