MetaCyc Pathway: anaerobic aromatic compound degradation (Thauera aromatica) in Cupriavidus basilensis FW507-4G11

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Anthranilate--CoA ligase:
anthranilate + ATP + coenzyme A→anthraniloyl-CoA + AMP + diphosphate (EC 6.2.1.32)
RR42_RS13535
Benzoate--CoA ligase:
benzoate + ATP + coenzyme A→benzoyl-CoA + AMP + diphosphate (EC 6.2.1.25)
RR42_RS07520
RR42_RS09890
RR42_RS35150
phenol + ATP + H2O→phenyl phosphate + AMP + 2 H+ + phosphate (EC 2.7.1.238)
No genes
Aspartate transaminase:
L-phenylalanine + 2-oxoglutarate→3-phenyl-2-oxopropanoate + L-glutamate (EC 2.6.1.1; 2.6.1.27; 2.6.1.57)
RR42_RS01570
RR42_RS01590
RR42_RS02275
RR42_RS04465
RR42_RS04985
RR42_RS05770
RR42_RS05990
RR42_RS09190
RR42_RS09965
RR42_RS10785
RR42_RS12545
RR42_RS14560
RR42_RS15580
RR42_RS16470
RR42_RS18910
RR42_RS21340
RR42_RS25980
RR42_RS26005
RR42_RS26015
RR42_RS26185
RR42_RS26625
RR42_RS28185
RR42_RS32165
RR42_RS33140
RR42_RS33490
RR42_RS33805
RR42_RS35305
RR42_RS36780
Benzylsuccinate synthase (in reverse):
toluene + fumarate→(R)-2-benzylsuccinate (EC 4.1.99.11)
No genes
anthraniloyl-CoA→benzoyl-CoA + ammonium
No genes
phenyl phosphate + CO2 + H2O→4-hydroxybenzoate + H+ + phosphate (EC 4.1.1.123)
No genes
Phenylpyruvate decarboxylase:
3-phenyl-2-oxopropanoate + H+→phenylacetaldehyde + CO2 (EC 4.1.1.43)
No genes
Succinyl-CoA:(R)-benzylsuccinate CoA-transferase:
(R)-2-benzylsuccinate + succinyl-CoA→(R)-benzylsuccinyl-CoA + succinate (EC 2.8.3.15)
No genes
4-hydroxybenzoate--CoA ligase:
4-hydroxybenzoate + ATP + coenzyme A→4-hydroxybenzoyl-CoA + AMP + diphosphate (EC 6.2.1.27)
No genes
Phenylacetaldehyde dehydrogenase:
phenylacetaldehyde + NAD+ + H2O→phenylacetate + NADH + 2 H+ (EC 1.2.1.39)
RR42_RS32140
(R)-benzylsuccinyl-CoA + an oxidized electron-transfer flavoprotein + H+→(E)-2-benzylidenesuccinyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.3)
RR42_RS25910
4-hydroxybenzoyl-CoA + 2 H+ + a reduced 2[4Fe-4s] ferredoxin→benzoyl-CoA + an oxidized 2[4Fe-4s] ferredoxin + H2O (EC 1.1.7.1)
No genes
Phenylacetate--CoA ligase:
phenylacetate + ATP + coenzyme A→phenylacetyl-CoA + AMP + diphosphate (EC 6.2.1.30)
RR42_RS01655
RR42_RS18265
RR42_RS23755
(E)-2-benzylidenesuccinyl-CoA + H2O→(2S)-2-[(R)-α-hydroxybenzyl]succinyl-CoA (EC 4.2.1.180)
No genes
Phenylacetyl-CoA dehydrogenase:
phenylacetyl-CoA + 2 a quinone + H2O→phenylglyoxylyl-CoA + 2 a quinol (EC 1.17.5.1)
No genes
(2S)-2-[(R)-α-hydroxybenzyl]succinyl-CoA + NAD+→(S)-2-benzoylsuccinyl-CoA + NADH + H+ (EC 1.1.1.429)
No genes
Phenylacetyl-CoA hydrolase:
phenylglyoxylyl-CoA + H2O→phenylglyoxylate + coenzyme A + H+ (EC 3.1.2.25)
No genes
(S)-2-benzoylsuccinyl-CoA + coenzyme A→benzoyl-CoA + succinyl-CoA (EC 2.3.1.310)
No genes
Phenylglyoxylate dehydrogenase (acylating):
phenylglyoxylate + coenzyme A + NAD+→benzoyl-CoA + CO2 + NADH (EC 1.2.1.58)
No genes
benzoyl-CoA + 2 ATP + 2 a reduced ferredoxin [iron-sulfur] cluster + 2 H2O→cyclohex-1,5-diene-1-carbonyl-CoA + 2 ADP + 2 an oxidized ferredoxin [iron-sulfur] cluster + 2 phosphate (EC 1.3.7.8)
No genes
Cyclohexa-1,5-dienecarbonyl-CoA hydratase (in reverse):
cyclohex-1,5-diene-1-carbonyl-CoA + H2O→6-hydroxycyclohex-1-ene-1-carbonyl-CoA (EC 4.2.1.100)
No genes
6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD+→6-oxocyclohex-1-ene-1-carbonyl-CoA + NADH + H+ (EC 1.1.1.368)
No genes
6-oxocyclohex-1-ene-1-carbonyl-CoA + H2O→2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA (EC 3.7.1.21)
No genes
2-hydroxy-6-oxocyclohexane-1-carbonyl-CoA + H2O→3-hydroxypimeloyl-CoA + H+ (EC 3.7.1.21)
No genes
3-hydroxypimeloyl-CoA dehydrogenase:
3-hydroxypimeloyl-CoA + NAD+→3-oxopimeloyl-CoA + NADH + H+ (EC 1.1.1.259)
No genes
3-oxopimeloyl-CoA + coenzyme A→glutaryl-CoA + acetyl-CoA
RR42_RS10260
RR42_RS31890

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information