MetaCyc Pathway: superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation in Cupriavidus basilensis FW507-4G11

Add experiment(s):


Arginine decarboxylase:
L-arginine + H+→agmatine + CO2 (EC 4.1.1.19)
RR42_RS15940
RR42_RS26025
Agmatinase:
agmatine + H2O→putrescine + urea (EC 3.5.3.11)
RR42_RS02455
Putrescine aminotransferase:
putrescine + 2-oxoglutarate→4-aminobutanal + L-glutamate (EC 2.6.1.82)
No genes
Glutamate--putrescine ligase:
putrescine + ATP + L-glutamate→γ-glutamyl-L-putrescine + ADP + H+ + phosphate (EC 6.3.1.11)
No genes
Aminobutyraldehyde dehydrogenase:
4-aminobutanal + NAD+ + H2O→4-aminobutanoate + NADH + 2 H+ (EC 1.2.1.19)
RR42_RS04280
RR42_RS06495
RR42_RS11360
RR42_RS13660
RR42_RS21485
RR42_RS24065
RR42_RS24390
RR42_RS24840
RR42_RS25005
RR42_RS25010
RR42_RS26255
RR42_RS27780
RR42_RS29955
RR42_RS32140
RR42_RS34255
γ-glutamyl-L-putrescine + dioxygen + H2O→4-(γ-L-glutamylamino)butanal + ammonium + hydrogen peroxide (EC 1.4.3.M3)
No genes
4-(γ-L-glutamylamino)butanal + NAD(P)+ + H2O→4-(γ-L-glutamylamino)butanoate + NAD(P)H + 2 H+ (EC 1.2.1.99)
No genes
Gamma-glutamyl-gamma-aminobutyrate hydrolase:
4-(γ-L-glutamylamino)butanoate + H2O→4-aminobutanoate + L-glutamate (EC 3.5.1.94)
No genes
4-aminobutyrate transaminase:
4-aminobutanoate + 2-oxoglutarate→succinate semialdehyde + L-glutamate (EC 2.6.1.19)
RR42_RS21370
RR42_RS26160
RR42_RS26240
Succinate-semialdehyde dehydrogenase:
succinate semialdehyde + NAD+ + H2O→succinate + NADH + 2 H+ (EC 1.2.1.24)
No genes
succinate semialdehyde + NADP+ + H2O→succinate + NADPH + 2 H+ (EC 1.2.1.79)
No genes

Links:

Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information