MetaCyc Pathway: superpathway of purines degradation in plants in Cupriavidus basilensis FW507-4G11

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Reactions and Genes Carbon source Deoxyribonucleic from herring sperm 10 mg/mL
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Adenosine-phosphate deaminase:
AMP + H+ + H2O→IMP + ammonium (EC 3.5.4.17; 3.5.4.6)
No genes
5'-nucleotidase:
GMP + H2O→guanosine + phosphate (EC 3.1.3.5)
RR42_RS01130 +0.1
RR42_RS13200 +0.1
RR42_RS32020 -0.7
RR42_RS32200 N.D.
RR42_RS34235 +0.5
Guanosine deaminase:
guanosine + H+ + H2O→xanthosine + ammonium (EC 3.5.4.15)
No genes
IMP dehydrogenase:
IMP + NAD+ + H2O→XMP + NADH + H+ (EC 1.1.1.205)
RR42_RS00320 -0.1
RR42_RS06470 -1.4
RR42_RS11750 N.D.
5'-nucleotidase:
IMP + H2O→inosine + phosphate (EC 3.1.3.5; 3.1.3.99)
RR42_RS01130 +0.1
RR42_RS13200 +0.1
RR42_RS32020 -0.7
RR42_RS32200 N.D.
RR42_RS34235 +0.5
Purine nucleosidase:
guanosine + H2O→guanine + D-ribofuranose (EC 3.2.2.1)
No genes
Guanine deaminase:
guanine + H+ + H2O→xanthine + ammonium (EC 3.5.4.3)
RR42_RS05320 -0.5
RR42_RS07300 +0.1
Inosine nucleosidase:
inosine + H2O→hypoxanthine + D-ribofuranose (EC 3.2.2.2)
No genes
5'-nucleotidase:
XMP + H2O→xanthosine + phosphate (EC 3.1.3.5)
RR42_RS01130 +0.1
RR42_RS13200 +0.1
RR42_RS32020 -0.7
RR42_RS32200 N.D.
RR42_RS34235 +0.5
Xanthine dehydrogenase:
hypoxanthine + NAD+ + H2O→xanthine + NADH + H+ (EC 1.17.1.4)
RR42_RS05335 -1.5
RR42_RS05340 -1.9
RR42_RS13620 -0.6
RR42_RS13625 -0.3
RR42_RS13630 -0.2
Purine nucleosidase:
xanthosine + H2O→xanthine + D-ribofuranose (EC 3.2.2.1)
No genes
Xanthine dehydrogenase:
xanthine + NAD+ + H2O→urate + NADH + H+ (EC 1.17.1.4)
RR42_RS05335 -1.5
RR42_RS05340 -1.9
RR42_RS13620 -0.6
RR42_RS13625 -0.3
RR42_RS13630 -0.2
Urate oxidase:
urate + dioxygen + H2O→(S)-5-hydroxyisourate + hydrogen peroxide (EC 1.7.3.3)
RR42_RS05255 -3.5
RR42_RS16400 -0.4
RR42_RS32355 -0.2
Hydroxyisourate hydrolase:
(S)-5-hydroxyisourate + H2O→(S)-2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline + H+ (EC 3.5.2.17)
RR42_RS05270 -2.3
(S)-2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline + H+→(S)-(+)-allantoin + CO2 (EC 4.1.1.97)
No genes
Allantoinase:
(S)-(+)-allantoin + H2O→allantoate + H+ (EC 3.5.2.5)
RR42_RS30230 -0.1
Allantoicase:
allantoate + H2O→(S)-ureidoglycolate + urea (EC 3.5.3.4)
No genes
Ureidoglycolate lyase:
(S)-ureidoglycolate→glyoxylate + urea (EC 4.3.2.3)
RR42_RS26285 -0.2

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information