MetaCyc Pathway: superpathway of L-tyrosine biosynthesis in Cupriavidus basilensis FW507-4G11

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Reactions and Genes nitrate (N)
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3-deoxy-7-phosphoheptulonate synthase:
D-erythrose 4-phosphate + phosphoenolpyruvate + H2O→3-deoxy-D-arabino-heptulosonate 7-phosphate + phosphate (EC 2.5.1.54)
RR42_RS05860 -7.0
3-dehydroquinate synthase:
3-deoxy-D-arabino-heptulosonate 7-phosphate→3-dehydroquinate + phosphate (EC 4.2.3.4)
RR42_RS19005 -4.6
3-dehydroquinate dehydratase:
3-dehydroquinate→3-dehydroshikimate + H2O (EC 4.2.1.10)
RR42_RS06175 N.D.
RR42_RS17690 -1.9
RR42_RS32450 -0.2
RR42_RS33730 +0.0
Shikimate dehydrogenase (in reverse):
3-dehydroshikimate + NADPH + H+→shikimate + NADP+ (EC 1.1.1.25)
RR42_RS09460 -0.1
RR42_RS17645 -3.3
RR42_RS21755 +0.7
RR42_RS32445 +0.5
Shikimate kinase:
shikimate + ATP→shikimate 3-phosphate + ADP + H+ (EC 2.7.1.71)
RR42_RS07515 +0.1
RR42_RS19010 -3.6
RR42_RS32495 +0.1
RR42_RS35135 +0.3
3-phosphoshikimate 1-carboxyvinyltransferase:
shikimate 3-phosphate + phosphoenolpyruvate→5-enolpyruvoyl-shikimate 3-phosphate + phosphate (EC 2.5.1.19)
RR42_RS04475 -4.4
Chorismate synthase:
5-enolpyruvoyl-shikimate 3-phosphate→chorismate + phosphate (EC 4.2.3.5)
RR42_RS06485 -5.9
Chorismate mutase:
chorismate→prephenate (EC 5.4.99.5)
RR42_RS04460 -3.0
Prephenate dehydrogenase:
prephenate + NAD+→3-(4-hydroxyphenyl)pyruvate + CO2 + NADH (EC 1.3.1.12)
RR42_RS04470 -1.6
Aspartate transaminase (in reverse):
3-(4-hydroxyphenyl)pyruvate + L-glutamate→L-tyrosine + 2-oxoglutarate (EC 2.6.1.1; 2.6.1.27; 2.6.1.5; 2.6.1.57)
RR42_RS01570 -0.1
RR42_RS01590 +0.3
RR42_RS02275 +0.2
RR42_RS04465 +0.1
RR42_RS04985 -0.2
RR42_RS05770 -0.1
RR42_RS05990 -3.0
RR42_RS09190 -0.1
RR42_RS09965 +0.1
RR42_RS10785 -0.0
RR42_RS12545 -0.4
RR42_RS14560 -0.1
RR42_RS15580 +0.1
RR42_RS16470 +0.2
RR42_RS18910 N.D.
RR42_RS21340 -0.1
RR42_RS25980 +0.0
RR42_RS26005 +0.1
RR42_RS26015 +0.0
RR42_RS26185 -0.0
RR42_RS26625 -0.0
RR42_RS28185 +0.0
RR42_RS32165 +0.1
RR42_RS33140 +0.1
RR42_RS33490 +0.1
RR42_RS33805 +0.1
RR42_RS35305 +0.1
RR42_RS36780 +0.1

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information