MetaCyc Pathway: superpathway of L-tryptophan biosynthesis in Cupriavidus basilensis FW507-4G11

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Reactions and Genes nitrate (N)
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3-deoxy-7-phosphoheptulonate synthase:
D-erythrose 4-phosphate + phosphoenolpyruvate + H2O→3-deoxy-D-arabino-heptulosonate 7-phosphate + phosphate (EC 2.5.1.54)
RR42_RS05860 -7.0
3-dehydroquinate synthase:
3-deoxy-D-arabino-heptulosonate 7-phosphate→3-dehydroquinate + phosphate (EC 4.2.3.4)
RR42_RS19005 -4.6
3-dehydroquinate dehydratase:
3-dehydroquinate→3-dehydroshikimate + H2O (EC 4.2.1.10)
RR42_RS06175 N.D.
RR42_RS17690 -1.9
RR42_RS32450 -0.2
RR42_RS33730 +0.0
Shikimate dehydrogenase (in reverse):
3-dehydroshikimate + NADPH + H+→shikimate + NADP+ (EC 1.1.1.25)
RR42_RS09460 -0.1
RR42_RS17645 -3.3
RR42_RS21755 +0.7
RR42_RS32445 +0.5
Shikimate kinase:
shikimate + ATP→shikimate 3-phosphate + ADP + H+ (EC 2.7.1.71)
RR42_RS07515 +0.1
RR42_RS19010 -3.6
RR42_RS32495 +0.1
RR42_RS35135 +0.3
3-phosphoshikimate 1-carboxyvinyltransferase:
shikimate 3-phosphate + phosphoenolpyruvate→5-enolpyruvoyl-shikimate 3-phosphate + phosphate (EC 2.5.1.19)
RR42_RS04475 -4.4
Chorismate synthase:
5-enolpyruvoyl-shikimate 3-phosphate→chorismate + phosphate (EC 4.2.3.5)
RR42_RS06485 -5.9
Anthranilate synthase:
chorismate + L-glutamine→anthranilate + L-glutamate + H+ + pyruvate (EC 4.1.3.27)
RR42_RS18295 -4.8
RR42_RS18300 -4.9
Anthranilate phosphoribosyltransferase (in reverse):
anthranilate + 5-phospho-α-D-ribose 1-diphosphate→N-(5-phosphoribosyl)-anthranilate + diphosphate (EC 2.4.2.18)
RR42_RS01940 -0.9
RR42_RS18305 -5.0
Phosphoribosylanthranilate isomerase:
N-(5-phosphoribosyl)-anthranilate→1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate (EC 5.3.1.24)
RR42_RS14365 -5.0
Indole-3-glycerol-phosphate synthase:
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H+→(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O (EC 4.1.1.48)
RR42_RS18310 -1.5
Indole-3-glycerol-phosphate lyase:
(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate→indole + D-glyceraldehyde 3-phosphate (EC 4.1.2.8; 4.2.1.20)
RR42_RS14350 N.D.
RR42_RS14360 -3.2
indole + L-serine→L-tryptophan + H2O (EC 4.2.1.122; 4.2.1.20)
RR42_RS14350 N.D.
RR42_RS14360 -3.2

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information