MetaCyc Pathway: L-tryptophan degradation III (eukaryotic) in Cupriavidus basilensis FW507-4G11

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Reactions and Genes L-Tryptophan (N)
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Tryptophan 2,3-dioxygenase:
L-tryptophan + dioxygen→N-formyl-L-kynurenine (EC 1.13.11.11; 1.13.11.52)
RR42_RS15390 -3.4
Arylformamidase:
N-formyl-L-kynurenine + H2O→L-kynurenine + formate + H+ (EC 3.5.1.9)
RR42_RS15380 -2.8
RR42_RS33590 +0.1
Kynurenine 3-monooxygenase:
L-kynurenine + NADPH + dioxygen + H+→3-hydroxy-L-kynurenine + NADP+ + H2O (EC 1.14.13.9)
No genes
Kynureninase:
3-hydroxy-L-kynurenine + H2O→3-hydroxyanthranilate + L-alanine + H+ (EC 3.7.1.3)
RR42_RS15385 -4.3
3-hydroxyanthranilate 3,4-dioxygenase:
3-hydroxyanthranilate + dioxygen→2-amino-3-carboxymuconate-6-semialdehyde (EC 1.13.11.6)
RR42_RS05080 +0.7
Aminocarboxymuconate-semialdehyde decarboxylase:
2-amino-3-carboxymuconate-6-semialdehyde + H+→(2Z,4E)-2-amino-6-oxohexa-2,4-dienoate + CO2 (EC 4.1.1.45)
RR42_RS05075 +1.1
RR42_RS26470 +0.2
Aminomuconate-semialdehyde dehydrogenase:
(2Z,4E)-2-amino-6-oxohexa-2,4-dienoate + NAD+ + H2O→(2Z,4E)-2-aminomuconate + NADH + 2 H+ (EC 1.2.1.32)
RR42_RS05110 +0.3
RR42_RS32650 +0.1
2-aminomuconate deaminase:
(2Z,4E)-2-aminomuconate + H2O→(3E)-2-oxohex-3-enedioate + ammonium (EC 3.5.99.5)
RR42_RS05085 +1.5
(3E)-2-oxohex-3-enedioate + NADH + H+→2-oxoadipate + NAD+
No genes
2-oxoadipate + coenzyme A + NAD+→glutaryl-CoA + CO2 + NADH (EC 1.2.1.105)
No genes
glutaryl-CoA + an oxidized electron-transfer flavoprotein + H+→(E)-glutaconyl-CoA + a reduced electron-transfer flavoprotein (EC 1.3.8.6)
No genes
(E)-glutaconyl-CoA + H+→crotonyl-CoA + CO2 (EC 1.3.8.6)
No genes
crotonyl-CoA + H2O→(S)-3-hydroxybutanoyl-CoA (EC 4.2.1.150)
RR42_RS00730 +0.0
RR42_RS02510 -0.1
RR42_RS02525 +0.1
RR42_RS03015 +0.0
RR42_RS04550 +0.2
RR42_RS05755 -0.1
RR42_RS10250 +0.0
RR42_RS10265 -0.2
RR42_RS10270 -0.1
RR42_RS11095 +0.2
RR42_RS12500 +0.0
RR42_RS12795 -0.3
RR42_RS13545 N.D.
RR42_RS16175 +0.3
RR42_RS16790 +0.2
RR42_RS18250 -0.1
RR42_RS19805 -0.6
RR42_RS22630 -0.1
RR42_RS22680 +0.4
RR42_RS23295 +0.2
RR42_RS23450 +0.2
RR42_RS23710 -0.0
RR42_RS24355 -0.1
RR42_RS24895 +0.3
RR42_RS25480 -0.1
RR42_RS25525 +0.3
RR42_RS25900 +0.2
RR42_RS28050 N.D.
RR42_RS28325 +0.0
RR42_RS28330 -0.3
RR42_RS29425 -0.0
RR42_RS29465 +0.0
RR42_RS29940 -0.0
RR42_RS29945 -0.2
RR42_RS31580 +0.1
RR42_RS31935 -0.3
RR42_RS31945 -0.1
RR42_RS34175 -0.2
RR42_RS34180 -0.1
RR42_RS34905 +0.2
RR42_RS35270 -0.2
RR42_RS36495 +0.2
3-hydroxyacyl-CoA dehydrogenase:
(S)-3-hydroxybutanoyl-CoA + NAD+→acetoacetyl-CoA + NADH + H+ (EC 1.1.1.35)
RR42_RS01610 +0.3
RR42_RS02510 -0.1
RR42_RS03005 -0.4
RR42_RS03440 +0.0
RR42_RS05760 -0.6
RR42_RS10265 -0.2
RR42_RS11095 +0.2
RR42_RS22630 -0.1
RR42_RS24305 +0.1
RR42_RS25375 -0.0
RR42_RS28325 +0.0
RR42_RS29465 +0.0
RR42_RS31050 -0.0
RR42_RS35270 -0.2
Acetyl-CoA C-acyltransferase (in reverse):
acetoacetyl-CoA + coenzyme A→2 acetyl-CoA (EC 2.3.1.16; 2.3.1.9)
RR42_RS00885 -0.0
RR42_RS02515 N.D.
RR42_RS03010 -0.2
RR42_RS07610 -0.6
RR42_RS07645 N.D.
RR42_RS10260 -0.4
RR42_RS10540 -0.1
RR42_RS11085 -0.3
RR42_RS16595 -0.1
RR42_RS22625 -0.0
RR42_RS24300 +0.2
RR42_RS24970 -0.1
RR42_RS25210 -0.1
RR42_RS25380 -0.4
RR42_RS25455 -0.4
RR42_RS26090 -0.2
RR42_RS27160 -0.4
RR42_RS27235 -0.2
RR42_RS28055 +0.0
RR42_RS28390 -0.0
RR42_RS31890 +0.2
RR42_RS31920 -0.2
RR42_RS35915 -0.6
RR42_RS36320 -0.2
RR42_RS37020 +0.3

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information