MetaCyc Pathway: L-leucine degradation III in Cupriavidus basilensis FW507-4G11

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Reactions and Genes L-Isoleucine (N)
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Branched-chain-amino-acid transaminase:
L-leucine + 2-oxoglutarate→4-methyl-2-oxopentanoate + L-glutamate (EC 2.6.1.42; 2.6.1.6)
RR42_RS25890 -1.3
Branched-chain-2-oxoacid decarboxylase:
4-methyl-2-oxopentanoate + H+→3-methylbutanal + CO2 (EC 4.1.1.72)
No genes
Alcohol dehydrogenase (in reverse):
3-methylbutanal + NADH + H+→3-methylbutanol + NAD+ (EC 1.1.1.1)
RR42_RS09745 -0.1
RR42_RS10210 -0.2
RR42_RS10545 -0.0
RR42_RS11005 -0.2
RR42_RS18350 -0.0
RR42_RS24070 +0.1
RR42_RS24560 +0.0
RR42_RS25355 +0.2
RR42_RS25775 N.D.
RR42_RS28650 N.D.
RR42_RS32920 +0.0
RR42_RS34260 +0.0
RR42_RS34620 -0.2
RR42_RS36940 -0.5

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Candidate genes for each reaction are identified from best hits to MetaCyc; by matching EC numbers (which are assigned by TIGRFam, SEED, or best hits to KEGG); or by matching SEED roles to KEGG reactions to MetaCyc reactions. See the "Protein" tab of each gene for more information